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题目:: Effects of type II alveolar epithelial cells on T cell mitogenic responses to concanavalin A and purified protein derivatives.
作者:: Sato(Katsumasa),Shimizu(Toshiaki),Sano(Chiaki),Tomioka(Haruaki)
状态:: 发布时间2005-10-20 , 更新时间 2013-11-21
期刊:: Microbiol Immunol
摘要:: To investigate the role of type II alveolar epithelial cells during the T cell-dependent host immune response to Mycobacterium tuberculosis (MTB), effects of MTB-infected A-549 human type II alveolar epithelial cells (A-549 cells) on T cell mitogenesis in response to concanavalin A (Con A) and purified protein derivatives (PPD) were studied. Human peripheral blood mononuclear cells (PBMCs) were cocultivated with uninfected or MTB-infected A-549 cells and Con A-and PPD-induced T cell mitogeneses were examined, and the following findings were obtained. T cell mitogenesis was inhibited by uninfected as well as MTB-infected A-549 cells, even when a dual-chamber culture system was used to prevent direct cell contact between PBMCs and A-549 cells. Therefore, it appears that A-549 cells suppress T cell mitogenesis by producing some unknown humoral suppressor factors.
语言:: eng
DOI:

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