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PMID: 16234578 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The role of the complement system in innate immunity.

Immunologic research ·Vol. 33 ·No. 2 ·2005-00-00 ·Pages 103-12

Rus H, Cudrici C, Niculescu F

Abstract

Complement is a major component of innate immune system involved in defending against all the foreign pathogens through complement fragments that participate in opsonization, chemotaxis, and activation of leukocytes and through cytolysis by C5b-9 membrane attack complex. Bacterias and viruses have adapted in various ways to escape the complement activation, and they take advantage of the complement system by using the host complement receptors to infect various cells. Complement activation also participates in clearance of apoptotic cells and immune complexes. Moreover, at sublytic dose, C5b-9 was shown to promote cell survival. Recently it was also recognized that complement plays a key role in adaptive immunity by modulating and modifying the T cell responses. All these data suggest that complement activation constitutes a critical link between the innate and acquired immune responses.

MeSH Terms
Animals Apoptosis Cell Membrane/immunology Complement Activation/immunology Complement System Proteins/immunology Humans Immunity, Innate/immunology Infections/immunology
Chemicals
Complement System Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rus Horea
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. hrus@umaryland.edu
Cudrici Cornelia
Niculescu Florin
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1385/IR:33:2:103
Email
hrus@umaryland.edu
Published
2005-00-00
Pages
103-12
Language
English
Region
United States
NLM ID
8611087
Subset
IM
Grants
NINDS NIH HHS · R0-1 NS42011 · United States
External Links
PubMed source DOI: 10.1385/IR:33:2:103 View journal details
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