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PMID: 16205738 Published · ppublish English Journal Article

Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1.

Nature medicine ·Vol. 11 ·No. 11 ·2005-11-00 ·Pages 1170-2

Fätkenheuer G, Pozniak AL, Johnson MA, Plettenberg A, Staszewski S, Hoepelman AI, Saag MS, Goebel FD, Rockstroh JK, Dezube BJ, Jenkins TM, Medhurst C, Sullivan JF, Ridgway C, Abel S, James IT, Youle M, van der Ryst E

Abstract

We assessed the efficacy and safety of 10-d monotherapy with the orally administered CCR5 antagonist maraviroc in 63 HIV-1-positive individuals prescreened for the absence of CXCR4-using virus. Maximum reduction in viral load occurred at a median of 10-15 d, with a mean reduction of >or=1.6 log(10) copies/ml at all twice daily doses >or=100 mg. These results provide proof of concept that CCR5 antagonism is a viable antiretroviral therapeutic approach.

MeSH Terms

Anti-HIV Agents/administration & dosage,adverse effects,therapeutic use Area Under Curve CCR5 Receptor Antagonists Clinical Trials, Phase II as Topic Cyclohexanes/antagonists & inhibitors,therapeutic use Dose-Response Relationship, Drug HIV Infections/blood,drug therapy,virology HIV-1/drug effects Humans Maraviroc RNA, Viral/blood Randomized Controlled Trials as Topic Time Factors Treatment Outcome Triazoles/antagonists & inhibitors,therapeutic use Viral Load/statistics & numerical data

Chemicals

Anti-HIV Agents CCR5 Receptor Antagonists Cyclohexanes RNA, Viral Triazoles Maraviroc

Authors & Affiliations

18 authors, click to expand affiliations / ORCID

Fätkenheuer Gerd

Department of Internal Medicine, Division of Infectious Diseases, Haus 11, University of Cologne, Joseph-Stelzmann-Strasse 9, D-50924 Cologne, Germany.

Pozniak Anton L

Johnson Margaret A

Plettenberg Andreas

Staszewski Schlomo

Hoepelman Andy I M

Saag Michael S

Goebel Frank D

Rockstroh Jürgen K

Dezube Bruce J

Jenkins Tim M

Medhurst Christine

Sullivan John F

Ridgway Caroline

Abel Samantha

James Ian T

Youle Mike

van der Ryst Elna

Article Info

Journal

Nature medicine

Abbr.

Nat Med

ISSN

1078-8956

DOI

10.1038/nm1319

Published

2005-11-00

Epub

2005-00-05

Pages

1170-2

Language

English

Region

United States

NLM ID

9502015

Subset

External Links

PubMed source DOI: 10.1038/nm1319 View journal details

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Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1.

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