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PMID: 16195246 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Neuroanatomical correlates of behavioural disorders in dementia.

Brain : a journal of neurology ·Vol. 128 ·No. Pt 11 ·2005-11-00 ·Pages 2612-25

Rosen HJ, Allison SC, Schauer GF, Gorno-Tempini ML, Weiner MW, Miller BL

Abstract

Neurodegenerative diseases are associated with profound changes in social and emotional function. The emergence of increasingly sophisticated methods for measuring brain volume has facilitated correlation of local changes in tissue content with cognitive and behavioural changes in neurodegenerative disease. The current study examined neuroanatomical correlates of behavioural abnormalities, as measured by the Neuropsychiatric Inventory, in 148 patients with dementia using voxel-based morphometry. Of 12 behaviours examined, 4 correlated with tissue loss: apathy, disinhibition, eating disorders and aberrant motor behaviour. Increasing severity across these four behaviours was associated with tissue loss in the ventral portion of the right anterior cingulate cortex (vACC) and adjacent ventromedial superior frontal gyrus (vmSFG), the right ventromedial prefrontal cortex (VMPC) more posteriorly, the right lateral middle frontal gyrus, the right caudate head, the right orbitofrontal cortex and the right anterior insula. In addition, apathy was independently associated with tissue loss in the right vmSFG, disinhibition with tissue loss in the right subgenual cingulate gyrus in the VMPC, and aberrant motor behaviour with tissue loss in the right dorsal ACC and left premotor cortex. These data strongly support the involvement of the right hemisphere in mediating social and emotional behaviour and highlight the importance of distinct regions on the medial wall of the right frontal lobe in regulating different behaviours. Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions.

MeSH Terms
Aged Brain Mapping/methods Dementia/pathology,psychology Feeding and Eating Disorders/etiology,pathology Female Gyrus Cinguli/pathology Humans Magnetic Resonance Imaging/methods Male Middle Aged Motivation Neuropsychological Tests Psychometrics Psychomotor Performance Social Behavior Disorders/etiology,pathology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rosen Howard J
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143-1207, USA. hrosen@memory.ucsf.edu
Allison Stephen C
Schauer Guido F
Gorno-Tempini Maria Luisa
Weiner Michael W
Miller Bruce L
References (107)
107 references, click to expand
  1. Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease.
    Ann Neurol. 2001 Mar;49(3):355-61 PMID: 11261510
  2. Deformation tensor morphometry of semantic dementia with quantitative validation.
    Neuroimage. 2004 Apr;21(4):1387-98 PMID: 15050564
  3. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness.
    Am J Psychiatry. 1999 May;156(5):675-82 PMID: 10327898
  4. Patterns of brain atrophy in frontotemporal dementia and semantic dementia.
    Neurology. 2002 Jan 22;58(2):198-208 PMID: 11805245
  5. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder.
    Arch Gen Psychiatry. 2004 Jun;61(6):564-76 PMID: 15184236
  6. Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications.
    Neurology. 2003 Nov 11;61(9):1196-203 PMID: 14610120
  7. Neural activity relating to generation and representation of galvanic skin conductance responses: a functional magnetic resonance imaging study.
    J Neurosci. 2000 Apr 15;20(8):3033-40 PMID: 10751455
  8. Approach-withdrawal and cerebral asymmetry: emotional expression and brain physiology. I.
    J Pers Soc Psychol. 1990 Feb;58(2):330-41 PMID: 2319445
  9. Extinction learning in humans: role of the amygdala and vmPFC.
    Neuron. 2004 Sep 16;43(6):897-905 PMID: 15363399
  10. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.
    Neurology. 1997 May;48(5 Suppl 6):S10-6 PMID: 9153155
  11. Face and voice expression identification in patients with emotional and behavioural changes following ventral frontal lobe damage.
    Neuropsychologia. 1996 Apr;34(4):247-61 PMID: 8657356
  12. Distinct behavioural profiles in frontotemporal dementia and semantic dementia.
    J Neurol Neurosurg Psychiatry. 2001 Mar;70(3):323-32 PMID: 11181853
  13. Differential impact of right and left hemisphere lesions on facial emotion and object imagery.
    Brain. 1991 Dec;114 ( Pt 6):2593-609 PMID: 1782533
  14. Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update.
    J Psychosom Res. 2002 Aug;53(2):647-54 PMID: 12169339
  15. The influence of right frontotemporal dysfunction on social behavior in frontotemporal dementia.
    Neurology. 2001 Jun;56(11 Suppl 4):S11-5 PMID: 11402144
  16. Current directions in social cognitive neuroscience.
    Curr Opin Neurobiol. 2004 Apr;14(2):254-8 PMID: 15082333
  17. Emotion, cognition, and behavior.
    Science. 2002 Nov 8;298(5596):1191-4 PMID: 12424363
  18. Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry.
    Neuroimage. 2002 Oct;17(2):618-30 PMID: 12377138
  19. The delusions of Capgras and intermetamorphosis in a patient with right-hemisphere white-matter pathology.
    Psychopathology. 2001 Nov-Dec;34(6):299-304 PMID: 11847489
  20. Motor areas of the medial wall: a review of their location and functional activation.
    Cereb Cortex. 1996 May-Jun;6(3):342-53 PMID: 8670662
  21. Renewal of the neurophysiology of language: functional neuroimaging.
    Physiol Rev. 2005 Jan;85(1):49-95 PMID: 15618478
  22. Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR.
    Neurology. 1985 Dec;35(12):1731-41 PMID: 4069365
  23. Cognition and anatomy in three variants of primary progressive aphasia.
    Ann Neurol. 2004 Mar;55(3):335-46 PMID: 14991811
  24. Why voxel-based morphometric analysis should be used with great caution when characterizing group differences.
    Neuroimage. 2004 Sep;23(1):17-20 PMID: 15325347
  25. Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease.
    Cogn Behav Neurol. 2003 Dec;16(4):211-8 PMID: 14665820
  26. Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia.
    Neurology. 2001 Jul 24;57(2):216-25 PMID: 11468305
  27. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease?
    J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):178-86 PMID: 10896690
  28. Amygdaloid atrophy in frontotemporal dementia and Alzheimer's disease.
    Neurosci Lett. 2002 Dec 25;335(2):139-43 PMID: 12459517
  29. Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease.
    J Neurol Neurosurg Psychiatry. 2002 Oct;73(4):371-6 PMID: 12235302
  30. Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type.
    Int Psychogeriatr. 1997;9 Suppl 1:173-6; discussion 177-8 PMID: 9447441
  31. "Voxel-based morphometry" should not be used with imperfectly registered images.
    Neuroimage. 2001 Dec;14(6):1454-62 PMID: 11707101
  32. Social cognitive neuroscience: where are we heading?
    Trends Cogn Sci. 2004 May;8(5):216-22 PMID: 15120680
  33. Behavioral disorders in the frontal and temporal variants of frontotemporal dementia.
    Neurology. 2004 Mar 9;62(5):742-8 PMID: 15007124
  34. Contributions of anterior cingulate cortex to behaviour.
    Brain. 1995 Feb;118 ( Pt 1):279-306 PMID: 7895011
  35. In search of the emotional self: an fMRI study using positive and negative emotional words.
    Am J Psychiatry. 2003 Nov;160(11):1938-45 PMID: 14594739
  36. A voxel-based morphometric study of ageing in 465 normal adult human brains.
    Neuroimage. 2001 Jul;14(1 Pt 1):21-36 PMID: 11525331
  37. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets.
    Neuroimage. 2003 Jul;19(3):1233-9 PMID: 12880848
  38. A comparison between the accuracy of voxel-based morphometry and hippocampal volumetry in Alzheimer's disease.
    J Magn Reson Imaging. 2004 Mar;19(3):274-82 PMID: 14994294
  39. Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias.
    Neuroimage. 2002 Sep;17(1):29-46 PMID: 12482066
  40. Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients.
    Neuroimage. 2001 May;13(5):896-902 PMID: 11304085
  41. The neuroanatomy of autism: a voxel-based whole brain analysis of structural scans.
    Neuroreport. 1999 Jun 3;10(8):1647-51 PMID: 10501551
  42. Rethinking feelings: an FMRI study of the cognitive regulation of emotion.
    J Cogn Neurosci. 2002 Nov 15;14(8):1215-29 PMID: 12495527
  43. Neural responses to facial and vocal expressions of fear and disgust.
    Proc Biol Sci. 1998 Oct 7;265(1408):1809-17 PMID: 9802236
  44. Abulia: a delphi survey of British neurologists and psychiatrists.
    Mov Disord. 2002 Sep;17(5):1052-7 PMID: 12360558
  45. Structural and functional dichotomy of human midcingulate cortex.
    Eur J Neurosci. 2003 Dec;18(11):3134-44 PMID: 14656310
  46. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.
    Am J Public Health. 1998 Sep;88(9):1337-42 PMID: 9736873
  47. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI.
    Neuroimage. 2002 Jun;16(2):331-48 PMID: 12030820
  48. Stereotaxic display of brain lesions.
    Behav Neurol. 2000;12(4):191-200 PMID: 11568431
  49. A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI.
    Neuroimage. 2003 Feb;18(2):263-72 PMID: 12595181
  50. Neuroanatomical correlates of pleasant and unpleasant emotion.
    Neuropsychologia. 1997 Nov;35(11):1437-44 PMID: 9352521
  51. Neural correlates of rapid reversal learning in a simple model of human social interaction.
    Neuroimage. 2003 Oct;20(2):1371-83 PMID: 14568506
  52. Emotions, behaviours and mood changes in stroke.
    Curr Opin Neurol. 2002 Feb;15(1):57-69 PMID: 11796952
  53. Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia.
    Ann Neurol. 2003;54 Suppl 5:S15-9 PMID: 12833363
  54. Asymmetric functional roles of right and left ventromedial prefrontal cortices in social conduct, decision-making, and emotional processing.
    Cortex. 2002 Sep;38(4):589-612 PMID: 12465670
  55. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop.
    Neurology. 1996 Jul;47(1):1-9 PMID: 8710059
  56. Apathy and loss of insight in Alzheimer's disease: a SPECT imaging study.
    J Neuropsychiatry Clin Neurosci. 1996 Winter;8(1):41-6 PMID: 8845700
  57. Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration.
    Ann Neurol. 2005 Feb;57(2):216-25 PMID: 15668960
  58. The orbitofrontal cortex and reward.
    Cereb Cortex. 2000 Mar;10(3):284-94 PMID: 10731223
  59. The temporal variant of frontotemporal dementia.
    Brain. 1997 Jun;120 ( Pt 6):1027-40 PMID: 9217686
  60. The anterior cingulate as a conflict monitor: fMRI and ERP studies.
    Physiol Behav. 2002 Dec;77(4-5):477-82 PMID: 12526986
  61. Spectrum of anterior cerebral artery territory infarction: clinical and MRI findings.
    Eur J Neurol. 2002 Nov;9(6):615-24 PMID: 12453077
  62. Brain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis.
    Psychiatry Res. 2002 Jun 15;114(2):103-11 PMID: 12036510
  63. Impaired fear conditioning in Alzheimer's disease.
    Neuropsychologia. 2002;40(8):1187-95 PMID: 11931922
  64. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains.
    Neuroimage. 2001 Sep;14(3):685-700 PMID: 11506541
  65. Delusions in Alzheimer's disease: spet evidence of right hemispheric dysfunction.
    Cortex. 1999 Sep;35(4):549-60 PMID: 10574080
  66. The functions of the orbitofrontal cortex.
    Brain Cogn. 2004 Jun;55(1):11-29 PMID: 15134840
  67. Frontal lobe dysfunction in secondary depression.
    J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):428-42 PMID: 7841814
  68. Impaired recognition and experience of disgust following brain injury.
    Nat Neurosci. 2000 Nov;3(11):1077-8 PMID: 11036262
  69. Distributional assumptions in voxel-based morphometry.
    Neuroimage. 2002 Oct;17(2):1027-30 PMID: 12377176
  70. Insensitivity to future consequences following damage to human prefrontal cortex.
    Cognition. 1994 Apr-Jun;50(1-3):7-15 PMID: 8039375
  71. Acute caudate vascular lesions.
    Stroke. 1999 Jan;30(1):100-8 PMID: 9880396
  72. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function.
    Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4259-64 PMID: 11259662
  73. Differential deficits in expression recognition in gene-carriers and patients with Huntington's disease.
    Neuropsychologia. 2003;41(11):1484-92 PMID: 12849766
  74. Dietary changes, compulsions and sexual behavior in frontotemporal degeneration.
    Dementia. 1995 Jul-Aug;6(4):195-9 PMID: 7550598
  75. Changes in cerebral morphology consequent to peripheral autonomic denervation.
    Neuroimage. 2003 Apr;18(4):908-16 PMID: 12725766
  76. Examining the relationship between computed tomography and neuropsychological measures in normal and demented elderly.
    J Neurol Neurosurg Psychiatry. 1984 Dec;47(12):1319-25 PMID: 6512552
  77. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria.
    Neurology. 1998 Dec;51(6):1546-54 PMID: 9855500
  78. Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment.
    J Mol Neurosci. 2003;20(3):241-8 PMID: 14501003
  79. Cortical systems for the recognition of emotion in facial expressions.
    J Neurosci. 1996 Dec 1;16(23):7678-87 PMID: 8922424
  80. Emotion comprehension in the temporal variant of frontotemporal dementia.
    Brain. 2002 Oct;125(Pt 10):2286-95 PMID: 12244085
  81. Interoception: the sense of the physiological condition of the body.
    Curr Opin Neurobiol. 2003 Aug;13(4):500-5 PMID: 12965300
  82. Alzheimer's disease and frontotemporal dementia exhibit distinct atrophy-behavior correlates: a computer-assisted imaging study.
    Acad Radiol. 2003 Dec;10(12):1392-401 PMID: 14697007
  83. Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia.
    Acta Neurol Scand. 2001 Jun;103(6):367-78 PMID: 11421849
  84. Kallmann's syndrome: mirror movements associated with bilateral corticospinal tract hypertrophy.
    Neurology. 1999 Mar 10;52(4):816-22 PMID: 10078733
  85. A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory.
    Ann Neurol. 2000 Jan;47(1):36-45 PMID: 10632099
  86. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.
    Neuroimage. 2002 Jan;15(1):273-89 PMID: 11771995
  87. Alzheimer disease and frontotemporal dementias. Behavioral distinctions.
    Arch Neurol. 1996 Jul;53(7):687-90 PMID: 8929178
  88. Neural correlates of semantic and behavioural deficits in frontotemporal dementia.
    Neuroimage. 2005 Feb 15;24(4):1042-51 PMID: 15670681
  89. Alzheimer's disease as a window to neural mechanisms of cognition.
    Neurology. 2003 Dec 9;61(11):1470-1 PMID: 14663024
  90. Functional neuroanatomy of amnesia: positron emission tomography studies.
    Microsc Res Tech. 2000 Oct 1;51(1):94-100 PMID: 11002357
  91. Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage.
    Neuropsychologia. 1991;29(12):1241-9 PMID: 1791934
  92. Dynamics of gray matter loss in Alzheimer's disease.
    J Neurosci. 2003 Feb 1;23(3):994-1005 PMID: 12574429
  93. A default mode of brain function.
    Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82 PMID: 11209064
  94. Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices.
    Brain. 2003 Jul;126(Pt 7):1691-712 PMID: 12805109
  95. Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment.
    Neurology. 2003 Dec 9;61(11):1485-91 PMID: 14663029
  96. Cerebral blood flow correlates of apathy in Alzheimer disease.
    Arch Neurol. 1996 Nov;53(11):1116-20 PMID: 8912484
  97. Right hemisphere emotional perception: evidence across multiple channels.
    Neuropsychology. 1998 Jul;12(3):446-58 PMID: 9673999
  98. Parallel organization of functionally segregated circuits linking basal ganglia and cortex.
    Annu Rev Neurosci. 1986;9:357-81 PMID: 3085570
  99. Progressive right frontotemporal degeneration: clinical, neuropsychological and SPECT characteristics.
    Dementia. 1993 May-Aug;4(3-4):204-13 PMID: 8401793
  100. Metabolic correlates of behavioral and affective disturbances in frontal lobe pathologies.
    J Neurol. 2003 Jul;250(7):827-33 PMID: 12883925
  101. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.
    Neurology. 1984 Jul;34(7):939-44 PMID: 6610841
  102. Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety.
    Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):688-93 PMID: 11209066
  103. Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging.
    Neuroimage. 2003 Jul;19(3):513-31 PMID: 12880784
  104. Thalamic atrophy in Huntington's disease co-varies with cognitive performance: a morphometric MRI analysis.
    Cereb Cortex. 2005 Jun;15(6):846-53 PMID: 15459079
  105. Voxel-based morphometry--the methods.
    Neuroimage. 2000 Jun;11(6 Pt 1):805-21 PMID: 10860804
  106. Why voxel-based morphometry should be used.
    Neuroimage. 2001 Dec;14(6):1238-43 PMID: 11707080
  107. Emotion and its disorders.
    Br Med Bull. 2003;65:35-47 PMID: 12697615
Article Info
Journal
Brain : a journal of neurology
Abbr.
Brain
ISSN
1460-2156
DOI
10.1093/brain/awh628
Email
hrosen@memory.ucsf.edu
Published
2005-11-00
Epub
2005-00-29
Pages
2612-25
Language
English
Region
England
NLM ID
0372537
PMCID
PMC1820861
Subset
IM
Grants
NIA NIH HHS · AG10129 · United States
NIA NIH HHS · K08 AG020760 · United States
NCRR NIH HHS · M01 RR000079 · United States
NIA NIH HHS · P50 AG005142 · United States
NIA NIH HHS · P50-AG05142 · United States
NIA NIH HHS · R01 AG010897 · United States
NCRR NIH HHS · M01 RR00079 · United States
NIA NIH HHS · 1K08AG020760-01 · United States
NIA NIH HHS · AG16570 · United States
NIA NIH HHS · P01 AG019724 · United States
NIA NIH HHS · P50 AG016570 · United States
NIA NIH HHS · P30 AG010129 · United States
External Links
PubMed source DOI: 10.1093/brain/awh628 PMC Full Text View journal details
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