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题目:: [Effect of PC-1 gene expression on migration ability of prostate cancer cells].
作者:: Zhang(Hui),Wan(Li-Chuan),Wang(Jian),Zhou(Jian-Guang),Huang(Cui-Fen)
状态:: 发布时间2005-09-14 , 更新时间 2015-03-13
期刊:: Ai Zheng
摘要:: PC-1 gene is highly expressed in C4-2 cell line, an androgen-independent and aggressive prostate cancer cell line, but lowly expressed in LNCaP cell line, an androgen-dependent prostate cancer cell line. This study was to assess the contribution of PC-1 gene to migration of prostate cancer cells.,LNCaP cell line with stable expression of PC-1 gene and C4-2 cell line with antisense nucleotide-down-regulated PC-1 were established. The migration abilities of LNCaP and C4-2 cells were tested using an in vitro transwell invasion assay.,Migration cell count of LNCaP cells with up-regulation of PC-1 gene was similar to that of control LNCaP cells(P>0.05); migration cell count was significantly lower in C4-2 cells with down-regulation of endogenous PC-1 gene than in control C4-2 cells (P<0.05).,PC-1 may be involved in the invasion of prostate cancer cells.
语言:: chi
DOI:

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