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PMID: 16151701 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The voltage-dependent anion channel in endoplasmic/sarcoplasmic reticulum: characterization, modulation and possible function.

The Journal of membrane biology ·Vol. 204 ·No. 2 ·2005-03-00 ·Pages 57-66

Shoshan-Barmatz V, Israelson A

Abstract

In recent years, it has been recognized that there is a metabolic coupling between the cytosol, ER/SR and mitochondria. In this cross-talk, mitochondrial Ca(2+) homeostasis and ATP production and supply play a major role. The primary transporter of adenine nucleotides, Ca(2+)and other metabolites into and out of mitochondria is the voltage-dependent anion channel (VDAC) located at the outer mitochondrial membrane, at a crucial position in the cell. VDAC has been established as a key player in mitochondrial metabolite and ion signaling and it has also been proposed that VDAC is present in extramitochondrial membranes. Thus, regulation of VDAC, as the main interface between mitochondrial and cellular metabolism, by other molecules is of utmost importance. This article reviews localization and function of VDAC, and focuses on VDAC as a skeletal muscle sarcoplasmic reticulum channel. The regulation of VDAC activity by associated proteins and by inhibitors is also presented. Several aspects of the physiological relevance of VDAC to Ca(2+) homeostasis and mitochondria-mediated apoptosis will be discussed.

MeSH Terms
Animals Apoptosis/physiology Calcium/metabolism Endoplasmic Reticulum/metabolism Intracellular Membranes/physiology Porins/physiology Sarcoplasmic Reticulum/metabolism Signal Transduction Voltage-Dependent Anion Channels
Chemicals
Porins Voltage-Dependent Anion Channels Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shoshan-Barmatz V
Department of Life Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel. vardasb@bgumail.bgu.ac.il
Israelson A
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Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/s00232-005-0749-4
Email
vardasb@bgumail.bgu.ac.il
Published
2005-03-00
Pages
57-66
Language
English
Region
United States
NLM ID
0211301
Subset
IM
External Links
PubMed source DOI: 10.1007/s00232-005-0749-4 View journal details
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