Diphenylprolinol methyl ether: a highly enantioselective catalyst for Michael addition of aldehydes to simple enones.

Organic letters ·Vol. 7 ·No. 19 ·2005-09-15 ·Pages 4253-6

Chi Y, Gellman SH

Abstract

[reaction: see text] Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95-99% ee) and significantly lower catalyst loadings than have been typical in this arena.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Chi Yonggui

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

Gellman Samuel H

Article Info

Journal

Organic letters

Abbr.

Org Lett

ISSN

1523-7060

DOI

10.1021/ol0517729

Published

2005-09-15

Pages

4253-6

Language

English

Region

United States

NLM ID

100890393

External Links

PubMed source DOI: 10.1021/ol0517729 View journal details

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Diphenylprolinol methyl ether: a highly enantioselective catalyst for Michael addition of aldehydes to simple enones.

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