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PMID: 16142675 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America ·Vol. 41 ·No. 7 ·2005-10-01 ·Pages 1053-6

Lambotte O, Boufassa F, Madec Y, Nguyen A, Goujard C, Meyer L, Rouzioux C, Venet A, Delfraissy JF, SEROCO-HEMOCO Study Group

Abstract

We identified a total 15 patients who have maintained undetectable plasma HIV RNA loads without antiretroviral treatment for >10 years from cohorts of 1300 and 1551 patients infected with human immunodeficiency virus (HIV). These 15 patients, whom we have referred to as "HIV controllers," are characterized by a low HIV DNA load in peripheral blood mononuclear cells and by a strong HIV-specific immune response.

MeSH Terms
Adult Aged CD8-Positive T-Lymphocytes/immunology Disease Progression Female HIV Infections/immunology,virology HIV-1/immunology,physiology Humans Male Middle Aged RNA, Viral/blood Time Factors Viral Load Virus Replication/physiology
Chemicals
RNA, Viral
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Lambotte Olivier
INSERM E-0109, Faculté de Médecine Paris-Sud, Université Paris XI, Service de Santé Publique, Bicêtre, France. olivier.lambotte@bct.ap-hop-paris.fr
Boufassa Faroudy
Madec Yoann
Nguyen Ahn
Goujard Cécile
Meyer Laurence
Rouzioux Christine
Venet Alain
Delfraissy Jean-François
SEROCO-HEMOCO Study Group
Article Info
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Abbr.
Clin Infect Dis
ISSN
1537-6591
DOI
10.1086/433188
Email
olivier.lambotte@bct.ap-hop-paris.fr
Published
2005-10-01
Epub
2005-00-30
Pages
1053-6
Language
English
Region
United States
NLM ID
9203213
Subset
IM
Corrections
ErratumIn
-
ErratumIn
-
External Links
PubMed source DOI: 10.1086/433188 View journal details
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