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PMID: 16141333 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Comparative physical mapping links conservation of microsynteny to chromosome structure and recombination in grasses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 102 ·No. 37 ·2005-09-13 ·Pages 13206-11

Bowers JE, Arias MA, Asher R, Avise JA, Ball RT, Brewer GA, Buss RW, Chen AH, Edwards TM, Estill JC, Exum HE, Goff VH, Herrick KL, Steele CL, Karunakaran S, Lafayette GK, Lemke C, Marler BS, Masters SL, McMillan JM, Nelson LK, Newsome GA, Nwakanma CC, Odeh RN, Phelps CA, Rarick EA, Rogers CJ, Ryan SP, Slaughter KA, Soderlund CA, Tang H, Wing RA, Paterson AH

Abstract

Nearly finished sequences for model organisms provide a foundation from which to explore genomic diversity among other taxonomic groups. We explore genome-wide microsynteny patterns between the rice sequence and two sorghum physical maps that integrate genetic markers, bacterial artificial chromosome (BAC) fingerprints, and BAC hybridization data. The sorghum maps largely tile a genomic component containing 41% of BACs but 80% of single-copy genes that shows conserved microsynteny with rice and partially tile a nonsyntenic component containing 46% of BACs but only 13% of single-copy genes. The remaining BACs are centromeric (4%) or unassigned (8%). The two genomic components correspond to cytologically discernible "euchromatin" and "heterochromatin." Gene and repetitive DNA distributions support this classification. Greater microcolinearity in recombinogenic (euchromatic) than nonrecombinogenic (heterochromatic) regions is consistent with the hypothesis that genomic rearrangements are usually deleterious, thus more likely to persist in nonrecombinogenic regions by virtue of Muller's ratchet. Interchromosomal centromeric rearrangements may have fostered diploidization of a polyploid cereal progenitor. Model plant sequences better guide studies of related genomes in recombinogenic than nonrecombinogenic regions. Bridging of 35 physical gaps in the rice sequence by sorghum BAC contigs illustrates reciprocal benefits of comparative approaches that extend at least across the cereals and perhaps beyond.

MeSH Terms
Base Sequence Chromosome Structures Euchromatin Genome, Plant Heterochromatin Molecular Sequence Data Oryza/genetics Physical Chromosome Mapping/methods Poaceae/genetics Recombination, Genetic Sorghum/genetics Synteny
Chemicals
Euchromatin Heterochromatin
Authors & Affiliations
33 authors, click to expand affiliations / ORCID
Bowers John E
Plant Genome Mapping Laboratory, University of Georgia, Athens, GA 30602, USA.
Arias Miguel A
Asher Rochelle
Avise Jennifer A
Ball Robert T
Brewer Gene A
Buss Ryan W
Chen Amy H
Edwards Thomas M
Estill James C
Exum Heather E
Goff Valorie H
Herrick Kristen L
Steele Cassie L James
Karunakaran Santhosh
Lafayette Gmerice K
Lemke Cornelia
Marler Barry S
Masters Shelley L
McMillan Joana M
Nelson Lisa K
Newsome Graham A
Nwakanma Chike C
Odeh Rosana N
Phelps Cynthia A
Rarick Elizabeth A
Rogers Carl J
Ryan Sean P
Slaughter Keimun A
Soderlund Carol A
Tang Haibao
Wing Rod A
Paterson Andrew H
References (35)
35 references, click to expand
  1. A tiling microarray expression analysis of rice chromosome 4 suggests a chromosome-level regulation of transcription.
    Plant Cell. 2005 Jun;17(6):1641-57 PMID: 15863518
  2. A bacterial artificial chromosome library for sugarcane.
    Theor Appl Genet. 1999 Aug;99(3-4):419-24 PMID: 22665173
  3. Duplication and DNA segmental loss in the rice genome: implications for diploidization.
    New Phytol. 2005 Mar;165(3):937-46 PMID: 15720704
  4. On the tetraploid origin of the maize genome.
    Comp Funct Genomics. 2004;5(3):281-4 PMID: 18629160
  5. A draft sequence of the rice genome (Oryza sativa L. ssp. japonica).
    Science. 2002 Apr 5;296(5565):92-100 PMID: 11935018
  6. Characterization of three maize bacterial artificial chromosome libraries toward anchoring of the physical map to the genetic map using high-density bacterial artificial chromosome filter hybridization.
    Plant Physiol. 2002 Dec;130(4):1686-96 PMID: 12481051
  7. The weediness of wild plants: molecular analysis of genes influencing dispersal and persistence of johnsongrass, Sorghum halepense (L.) Pers.
    Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6127-31 PMID: 11607551
  8. Sequence and analysis of rice chromosome 4.
    Nature. 2002 Nov 21;420(6913):316-20 PMID: 12447439
  9. Integration of Cot analysis, DNA cloning, and high-throughput sequencing facilitates genome characterization and gene discovery.
    Genome Res. 2002 May;12(5):795-807 PMID: 11997346
  10. Genetic, physical, and informatics resources for maize. On the road to an integrated map.
    Plant Physiol. 2002 Dec;130(4):1598-605 PMID: 12481043
  11. Retrotransposon-related DNA sequences in the centromeres of grass chromosomes.
    Genetics. 1998 Dec;150(4):1615-23 PMID: 9832537
  12. Segmental duplications: organization and impact within the current human genome project assembly.
    Genome Res. 2001 Jun;11(6):1005-17 PMID: 11381028
  13. High throughput fingerprint analysis of large-insert clones.
    Genome Res. 1997 Nov;7(11):1072-84 PMID: 9371743
  14. The genome sequence and structure of rice chromosome 1.
    Nature. 2002 Nov 21;420(6913):312-6 PMID: 12447438
  15. An SNP resource for rice genetics and breeding based on subspecies indica and japonica genome alignments.
    Genome Res. 2004 Sep;14(9):1812-9 PMID: 15342564
  16. Convergent domestication of cereal crops by independent mutations at corresponding genetic Loci.
    Science. 1995 Sep 22;269(5231):1714-8 PMID: 17821643
  17. Chromosome identification and nomenclature of Sorghum bicolor.
    Genetics. 2005 Feb;169(2):1169-73 PMID: 15489512
  18. A primitive Y chromosome in papaya marks incipient sex chromosome evolution.
    Nature. 2004 Jan 22;427(6972):348-52 PMID: 14737167
  19. Distribution and sequence analysis of the centromere-associated repetitive element CEN38 of Sorghum bicolor (Poaceae).
    Am J Bot. 2000 Dec;87(12):1757-64 PMID: 11118410
  20. Image analysis of restriction enzyme fingerprint autoradiograms.
    Comput Appl Biosci. 1989 Apr;5(2):101-6 PMID: 2720459
  21. Evolutionary dynamics of transposable elements at the centromere.
    Trends Genet. 2004 Dec;20(12):611-6 PMID: 15522456
  22. Toward a cytological characterization of the rice genome.
    Genome Res. 2001 Dec;11(12):2133-41 PMID: 11731505
  23. Construction and characterization of a bacterial artificial chromosome library of banana (Musa acuminata Colla).
    Theor Appl Genet. 2003 Apr;106(6):1102-6 PMID: 12671759
  24. The evolutionary fate and consequences of duplicate genes.
    Science. 2000 Nov 10;290(5494):1151-5 PMID: 11073452
  25. BAC end sequences and a physical map reveal transposable element content and clustering patterns in the genome of Magnaporthe grisea.
    Fungal Genet Biol. 2004 Jul;41(7):657-66 PMID: 15275661
  26. An anchored framework BAC map of mouse chromosome 11 assembled using multiplex oligonucleotide hybridization.
    Genomics. 1998 Dec 15;54(3):387-97 PMID: 9878241
  27. Ancient polyploidization predating divergence of the cereals, and its consequences for comparative genomics.
    Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9903-8 PMID: 15161969
  28. Detailed alignment of saccharum and sorghum chromosomes: comparative organization of closely related diploid and polyploid genomes.
    Genetics. 1998 Dec;150(4):1663-82 PMID: 9832541
  29. Sequencing of a rice centromere uncovers active genes.
    Nat Genet. 2004 Feb;36(2):138-45 PMID: 14716315
  30. A high-density genetic recombination map of sequence-tagged sites for sorghum, as a framework for comparative structural and evolutionary genomics of tropical grains and grasses.
    Genetics. 2003 Sep;165(1):367-86 PMID: 14504243
  31. High gene density is conserved at syntenic loci of small and large grass genomes.
    Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8265-70 PMID: 10393983
  32. The organization and rate of evolution of wheat genomes are correlated with recombination rates along chromosome arms.
    Genome Res. 2003 May;13(5):753-63 PMID: 12695326
  33. An integrated physical and genetic map of the rice genome.
    Plant Cell. 2002 Mar;14(3):537-45 PMID: 11910002
  34. Contigs built with fingerprints, markers, and FPC V4.7.
    Genome Res. 2000 Nov;10(11):1772-87 PMID: 11076862
  35. Identification of the duplicated segments in rice chromosomes 1 and 5 by linkage analysis of cDNA markers of known functions.
    Theor Appl Genet. 1994 Aug;88(6-7):722-6 PMID: 24186168
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0502365102
Published
2005-09-13
Epub
2005-00-02
Pages
13206-11
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1201573
Subset
IM
Databases
GENBANK
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BZ691920, BZ691921, BZ691922, BZ691923, BZ691924, BZ691925, BZ691926, BZ691927, BZ691928, BZ691929, BZ691930, BZ691931, BZ691932, BZ691933, BZ691934, BZ691935, BZ691936, BZ691937, BZ691938, BZ691939, BZ691940, BZ691941, BZ691942, BZ691943, BZ691944, BZ691945, BZ691946, BZ691947, BZ691948, BZ691949, BZ691950, BZ691951, BZ691952, BZ691953, BZ691954, BZ691955, BZ691956, BZ691957, BZ691958, BZ691959, BZ691960, BZ691961, BZ691962, BZ691963, BZ691964, BZ691965, BZ691966, BZ691967, BZ691968, BZ691969, BZ691970, BZ691971, BZ691972, BZ691973, BZ691974, BZ691975, BZ691976, BZ691977, BZ691978, BZ691979, BZ691980, BZ691981, BZ691982, BZ691983, BZ691984, BZ691985, BZ691986, BZ691987, BZ691988, BZ691989, BZ691990, BZ691991, BZ691992, BZ691993, BZ691994, BZ691995, BZ691996, BZ691997, BZ691998, BZ691999, BZ692000, BZ692001, BZ692002, BZ692003, BZ692004, BZ692005, BZ692006, BZ692007, BZ692008, BZ692009, BZ692010, BZ692011, BZ692012, BZ692013, BZ692014, BZ692015, BZ692016, BZ692017, BZ692018, BZ692019
External Links
PubMed source DOI: 10.1073/pnas.0502365102 PMC Full Text View journal details
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