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PMID: 16138184 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Mechanisms of sudden cardiac death.

The Journal of clinical investigation ·Vol. 115 ·No. 9 ·2005-09-00 ·Pages 2305-15

Rubart M, Zipes DP

Abstract

Despite recent advances in preventing sudden cardiac death (SCD) due to cardiac arrhythmia, its incidence in the population at large has remained unacceptably high. Better understanding of the interaction among various functional, structural, and genetic factors underlying the susceptibility to, and initiation of, fatal arrhythmias is a major goal and will provide new tools for the prediction, prevention, and therapy of SCD. Here, we review the role of aberrant intracellular Ca handling, ionic imbalances associated with acute myocardial ischemia, neurohumoral changes, and genetic predisposition in the pathogenesis of SCD due to cardiac arrhythmia. Therapeutic measures to prevent SCD are also discussed.

MeSH Terms
Action Potentials/physiology Arrhythmias, Cardiac/etiology,physiopathology Calcium/metabolism Death, Sudden, Cardiac/etiology Electrocardiography Genetic Predisposition to Disease Humans Ion Channels/metabolism Myocardial Ischemia/physiopathology Myocardium/metabolism Renin-Angiotensin System/physiology Second Messenger Systems/physiology
Chemicals
Ion Channels Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rubart Michael
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5225, USA. mrubartv@iupui.edu
Zipes Douglas P
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI26381
Email
mrubartv@iupui.edu
Published
2005-09-00
Pages
2305-15
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC1193893
Subset
IM
Grants
NHLBI NIH HHS · R01 HL075165 · United States
NHLBI NIH HHS · R01 HL075165-01A2 · United States
NHLBI NIH HHS · HL075165 · United States
External Links
PubMed source DOI: 10.1172/JCI26381 PMC Full Text View journal details
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