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PMID: 16125441 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

Comparative phylogenomics of pathogenic bacteria by microarray analysis.

Current opinion in microbiology ·Vol. 8 ·No. 5 ·2005-10-00 ·Pages 620-6

Dorrell N, Hinchliffe SJ, Wren BW

Abstract

DNA microarrays represent a powerful technology that enables whole-scale comparison of bacterial genomes. This, coupled with new methods to model DNA microarray data, is facilitating the development of robust comparative phylogenomics analyses. Such studies have dramatically increased our ability to differentiate between bacteria, highlighting previously undetected genetic differences and population structures and providing new insight into virulence and evolution of bacterial pathogens. Recent results from such studies have generated insights into the evolution of bacterial pathogens, the levels of diversity and plasticity in the genome of a species, as well as the differences in virulence amongst pathogenic bacteria.

MeSH Terms
Bacteria/classification,genetics,pathogenicity Genome, Bacterial Humans Microarray Analysis Oligonucleotide Array Sequence Analysis Virulence/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dorrell Nick
Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, United Kingdom.
Hinchliffe Stewart J
Wren Brendan W
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Article Info
Journal
Current opinion in microbiology
Abbr.
Curr Opin Microbiol
ISSN
1369-5274
Published
2005-10-00
Pages
620-6
Language
English
Region
England
NLM ID
9815056
PMCID
PMC7108221
Subset
IM
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