Checkpoints of melanocyte stem cell development.

Science's STKE : signal transduction knowledge environment ·Vol. 2005 ·No. 298 ·2005-08-23 ·Pages pe42

Sommer L

Abstract

The bulge region of the adult hair follicle contains the niches for both epithelial and melanocyte stem cells. Recent evidence suggests that the development of melanocyte stem cells is controlled by a complex network of transcription factors, including Pax3, Sox10, and Mitf, and of regulatory extracellular cues such as Wnt. However, additional players are likely to be involved. It will be intriguing to identify these signals and to elucidate whether and how neighboring epithelial stem cells influence the balance between melanocyte stem cell maintenance and differentiation.

MeSH Terms

Animals Biomarkers Cell Differentiation Cell Lineage Gene Expression Regulation Hair Color Hair Follicle/cytology High Mobility Group Proteins/physiology Intramolecular Oxidoreductases/physiology Melanocytes/cytology Mice Mice, Transgenic Microphthalmia-Associated Transcription Factor/physiology Multipotent Stem Cells/cytology Neoplasm Proteins/physiology Neural Crest/cytology PAX3 Transcription Factor Paired Box Transcription Factors/physiology SOXE Transcription Factors Transcription Factors/physiology Wnt Proteins/physiology

Chemicals

Biomarkers High Mobility Group Proteins Microphthalmia-Associated Transcription Factor Mitf protein, mouse Neoplasm Proteins PAX3 Transcription Factor Paired Box Transcription Factors SOXE Transcription Factors Sox10 protein, mouse Transcription Factors Wnt Proteins Pax3 protein, mouse Intramolecular Oxidoreductases dopachrome isomerase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Sommer Lukas

Institute of Cell Biology, Swiss Federal Institute of Technology, ETH-Hoenggerberg HPM E38, CH-8093 Zürich, Switzerland. lukas.sommer@cell.biol.ethz.ch

Article Info

Journal

Science's STKE : signal transduction knowledge environment

Abbr.

Sci STKE

ISSN

1525-8882

DOI

10.1126/stke.2982005pe42

lukas.sommer@cell.biol.ethz.ch

Published

2005-08-23

Epub

2005-00-23

Pages

pe42

Language

English

Region

United States

NLM ID

100964423

Subset

External Links

PubMed source DOI: 10.1126/stke.2982005pe42

Analysis Services

Checkpoints of melanocyte stem cell development.

Contact

WeChat Official Account