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PMID: 16091212 Published · ppublish English Journal Article Review

Structural biology of allergens.

Current allergy and asthma reports ·Vol. 5 ·No. 5 ·2005-09-00 ·Pages 388-93

Thomas WR, Hales BJ, Smith WA

Abstract

Major allergens may have special aerobiological properties and allergenic structures. It would also be instructive to consider the properties of nonallergens and nonallergenic responses. In some cases, nonallergenic responses appear to result from a lack of antigenicity and in others from regulation. Proteolytic activity has been proposed as an adjuvant for allergenicity, but lipid binding is far more common and is found for more than 50% of the major allergens. Such structures can enhance allergenicity via Toll-like receptor (TLR) or CD1 pathways. TLR signaling can enhance both Th1 and Th2 responses and be induced by peptides as well as nonproteinaceous ligands.

MeSH Terms
Allergens/chemistry,immunology,metabolism Animals Arthropods/immunology Humans Lipids/immunology Mammals/immunology Peptide Hydrolases/metabolism Pollen/immunology
Chemicals
Allergens Lipids Peptide Hydrolases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Thomas Wayne R
Centre for Child Health Research, Telethon Institute for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA 6872, Australia. wayne@ichr.uwa.edu.au
Hales Belinda J
Smith Wendy-Anne
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Article Info
Journal
Current allergy and asthma reports
Abbr.
Curr Allergy Asthma Rep
ISSN
1529-7322
DOI
10.1007/s11882-005-0012-1
Email
wayne@ichr.uwa.edu.au
Published
2005-09-00
Pages
388-93
Language
English
Region
United States
NLM ID
101096440
Subset
IM
External Links
PubMed source DOI: 10.1007/s11882-005-0012-1 View journal details
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