Home LiteratureArticle Details
PMID: 16073 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The Ly phenotype of suppressor T cells arising in mice subjected to a graft-versus-host reaction.

The Journal of experimental medicine ·Vol. 145 ·No. 5 ·1977-05-01 ·Pages 1169-75

Pickel K, Hoffmann MK

Abstract

T cells with helper and suppressor functions arising during graft-versus-host reaction (B6 vs. BDF1) have been characterized with respect to their Ly surface antigens. Helper cells were found to express the phenotype Ly 1+2- and suppressor cells the phenotype Ly 1+2+. Ly 1-2+ T cells had no suppressive effect in this system. T cells of the host did not contribute to either activity.

MeSH Terms
Animals Antibody Formation Antilymphocyte Serum Cells, Cultured Complement System Proteins Cytotoxicity Tests, Immunologic Female Graft vs Host Reaction Histocompatibility Antigens Immunosuppression Therapy Mice Mice, Inbred C57BL Mice, Inbred DBA Phenotype Spleen/immunology,transplantation T-Lymphocytes/immunology Time Factors
Chemicals
Antilymphocyte Serum Histocompatibility Antigens Complement System Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pickel K
Hoffmann M K
References (14)
14 references, click to expand
  1. Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.
    Nature. 1975 Dec 18;258(5536):614-6 PMID: 1082097
  2. Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.
    J Exp Med. 1976 Jun 1;143(6):1382-90 PMID: 1083887
  3. Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.
    J Exp Med. 1976 Jun 1;143(6):1391-40 PMID: 1083888
  4. T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.
    J Exp Med. 1976 Aug 1;144(2):330-44 PMID: 1085324
  5. Separation of suppressor and killer T cells by surgace phenotype.
    Nature. 1976 Aug 5;262(5568):495-7 PMID: 1085418
  6. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.
    J Exp Med. 1975 Jun 1;141(6):1376-89 PMID: 1092798
  7. Suppressor T cells arising in mice undergoing a graft-vs-host response.
    J Immunol. 1977 Feb;118(2):653-6 PMID: 14213
  8. Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse.
    Nature. 1975 Jan 17;253(5488):219-20 PMID: 234178
  9. Suppressive effect of graft versus host reactions on the immune response to heterologous red cells.
    Immunology. 1971 Apr;20(4):597-609 PMID: 4396490
  10. Antigenic competition in vitro of spleen cells subjected to a graft-versus-host reaction.
    Immunology. 1971 Aug;21(2):351-61 PMID: 4398350
  11. Effect of allogeneic cell interaction on the primary immune response in vitro. Cell types involved in suppression and stimulation of antibody synthesis.
    Clin Exp Immunol. 1972 Nov;12(3):365-75 PMID: 4404919
  12. The theory of the 'one nonspecific signal' model for b cell activation.
    Transplant Rev. 1975;23:49-65 PMID: 49105
  13. Immunization of dissociated spleen cell cultures from normal mice.
    J Exp Med. 1967 Sep 1;126(3):423-42 PMID: 6034749
  14. Ly phenotype of cytotoxic T cells for syngeneic tumor.
    J Exp Med. 1976 Oct 1;144(4):1116-20 PMID: 62011
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.145.5.1169
Published
1977-05-01
Pages
1169-75
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180659
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.145.5.1169 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2