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题目:: Interferon-alpha and dexamethasone inhibit adhesion of T cells to endothelial cells and synovial cells.
作者:: Eguchi(K),Kawakami(A),Nakashima(M),Ida(H),Sakito(S),Matsuoka(N),Terada(K),Sakai(M),Kawabe(Y),Fukuda(T)
状态:: 发布时间1992-07-17 , 更新时间 2014-11-20
期刊:: Clin Exp Immunol
摘要:: We investigated whether interferon-gamma (IFN-gamma), interferon-alpha (IFN-alpha) and glucocorticoids affected the adhesion of T cells to human umbilical endothelial cells or human synovial cells. About 30% of peripheral blood T cells could bind to unstimulated endothelial cells, but only a few T cells could bind to unstimulated synovial cells. When both endothelial cells and synovial cells were cultured with recombinant IFN-gamma (rIFN-gamma), the percentage of T cell binding to both types of cells increased in a dose-dependent manner. rIFN-alpha and dexamethasone blocked the T cell binding to unstimulated endothelial cells. Furthermore, rIFN-alpha and dexamethasone suppressed T cell binding to both endothelial cells and synovial cells stimulated by IFN-gamma, and also inhibited intercellular adhesion molecule-1 (ICAM-1) expression on both endothelial cells and synovial cells stimulated by IFN-gamma. These results suggest that IFN-alpha and glucocorticoids may inhibit T cell binding to endothelial cells or synovial cells by modulating adhesion molecule expression on these cells.
语言:: eng
DOI:

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