Messenger RNA surveillance: neutralizing natural nonsense.

Current biology : CB ·Vol. 15 ·No. 14 ·2005-07-26 ·Pages R559-62

Weischenfeldt J, Lykke-Andersen J, Porse B

Abstract

Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.

MeSH Terms

Animals Caenorhabditis elegans Codon, Nonsense/genetics Gene Expression Regulation/physiology Mice Models, Biological Pseudogenes/genetics RNA Helicases/metabolism RNA Stability/genetics,physiology RNA, Small Nucleolar/genetics

Chemicals

Codon, Nonsense RNA, Small Nucleolar RNA Helicases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Weischenfeldt Joachim

Section of Gene Therapy Research, Copenhagen University Hospital, Juliane Mariesvej 20 section 9322, DK-2100 Copenhagen, Denmark. Joachim.weischenfeldt@rh.hosp.dk

Lykke-Andersen Jens

Porse Bo

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/j.cub.2005.07.002

joachim.weischenfeldt@rh.hosp.dk

Published

2005-07-26

Pages

R559-62

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/j.cub.2005.07.002 View journal details

Analysis Services

Messenger RNA surveillance: neutralizing natural nonsense.

Contact

WeChat Official Account