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题目:
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells.
作者:
Philpott(K L),Viney(J L),Kay(G),Rastan(S),Gardiner(E M),Chae(S),Hayday(A C),Owen(M J)
状态:
发布时间1992-07-15 , 更新时间 2007-11-14
期刊:
Science
摘要:
Vertebrate T cells express either an alpha beta or gamma delta T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. alpha beta + T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of alpha beta + T cells on B cell development is poorly understood. To investigate the developmental effects of alpha beta + T cells on B cells and gamma delta + T cells, mice homozygous for a disrupted TCR alpha gene were generated. The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells.
语言:
eng
DOI:

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