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题目:: Regulatory T cells in autoimmune diseases: anti-ergotypic T cells.
作者:: Mimran(Avishai),Cohen(Irun R)
状态:: 发布时间2005-07-22 , 更新时间 2005-11-16
期刊:: Int Rev Immunol
摘要:: T regulatory cells play an important role in regulating T-cell responses to self-antigens and control autoimmunity and autoimmune disease. Anti-ergotypic T cells are a subset of such regulatory T cells that respond to activation markers, ergotopes, expressed on other activated T cells. Anti-ergotypic T cells do not respond to nonactivated T cells. Ergotopes include the a-chain of the IL-2 receptor (CD25). Anti-ergotypic T cells were found to downregulate experimental diseases such as experimental autoimmune encephalomyelitis (EAE) and adjuvant arthritis (AA). Anti-ergotypic T cells are present in humans and are activated after T-cell vaccination. Here we review anti-ergotypic T cells in animal models and in humans and contrast anti-ergotypic T cells with other regulatory T-cell subsets.
语言:: eng
DOI:: 10.1080/08830180590934949

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