Home LiteratureArticle Details
PMID: 16020725 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

Science (New York, N.Y.) ·Vol. 309 ·No. 5733 ·2005-07-15 ·Pages 409-15

El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S, Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M, Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B

Abstract

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.

MeSH Terms
Animals Chagas Disease/drug therapy,parasitology DNA Repair DNA Replication DNA, Mitochondrial/genetics DNA, Protozoan/genetics Genes, Protozoan Genome, Protozoan Humans Meiosis Membrane Proteins/chemistry,genetics,physiology Multigene Family Protozoan Proteins/chemistry,genetics,physiology Recombination, Genetic Repetitive Sequences, Nucleic Acid Retroelements Sequence Analysis, DNA Signal Transduction Telomere/genetics Trypanocidal Agents/pharmacology,therapeutic use Trypanosoma cruzi/chemistry,genetics,physiology
Chemicals
DNA, Mitochondrial DNA, Protozoan Membrane Proteins Protozoan Proteins Retroelements Trypanocidal Agents
Authors & Affiliations
82 authors, click to expand affiliations / ORCID
El-Sayed Najib M
Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA. nelsayed@tigr.org
Myler Peter J
Bartholomeu Daniella C
Nilsson Daniel
Aggarwal Gautam
Tran Anh-Nhi
Ghedin Elodie
Worthey Elizabeth A
Delcher Arthur L
Blandin Gaëlle
Westenberger Scott J
Caler Elisabet
Cerqueira Gustavo C
Branche Carole
Haas Brian
Anupama Atashi
Arner Erik
Aslund Lena
Attipoe Philip
Bontempi Esteban
Bringaud Frédéric
Burton Peter
Cadag Eithon
Campbell David A
Carrington Mark
Crabtree Jonathan
Darban Hamid
da Silveira Jose Franco
de Jong Pieter
Edwards Kimberly
Englund Paul T
Fazelina Gholam
Feldblyum Tamara
Ferella Marcela
Frasch Alberto Carlos
Gull Keith
Horn David
Hou Lihua
Huang Yiting
Kindlund Ellen
Klingbeil Michele
Kluge Sindy
Koo Hean
Lacerda Daniela
Levin Mariano J
Lorenzi Hernan
Louie Tin
Machado Carlos Renato
McCulloch Richard
McKenna Alan
Mizuno Yumi
Mottram Jeremy C
Nelson Siri
Ochaya Stephen
Osoegawa Kazutoyo
Pai Grace
Parsons Marilyn
Pentony Martin
Pettersson Ulf
Pop Mihai
Ramirez Jose Luis
Rinta Joel
Robertson Laura
Salzberg Steven L
Sanchez Daniel O
Seyler Amber
Sharma Reuben
Shetty Jyoti
Simpson Anjana J
Sisk Ellen
Tammi Martti T
Tarleton Rick
Teixeira Santuza
Van Aken Susan
Vogt Christy
Ward Pauline N
Wickstead Bill
Wortman Jennifer
White Owen
Fraser Claire M
Stuart Kenneth D
Andersson Björn
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2005-07-15
Pages
409-15
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIAID NIH HHS · R01 AI031077 · United States
NIAID NIH HHS · AI45061 · United States
NIAID NIH HHS · AI045039 · United States
NIAID NIH HHS · R01 AI031077-11 · United States
NIAID NIH HHS · U01 AI045039 · United States
NIAID NIH HHS · AI45038 · United States
NIAID NIH HHS · U01 AI045038 · United States
Wellcome Trust · United Kingdom
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com