The Light Green Cells of Lymnaea: a neuroendocrine model system for stimulus-induced expression of multiple peptide genes in a single cell type.

Experientia ·Vol. 48 ·No. 5 ·1992-05-15 ·Pages 464-73

Geraerts WP, Smit AB, Li KW, Hordijk PL

Abstract

We review recent experiments showing that the cerebral neuroendocrine Light Green Cells (LGCs) of the freshwater snail, Lymnaea stagnalis, express a family of distinct though related molluscan insulin-related peptide (MIP) genes. The LGCs are involved in the regulation of a wide range of interrelated life processes associated with growth, (energy) metabolism and reproduction. We consider the mechanism of generation of diversity among MIPs, and present evidence that conditions with distinct effects on growth, metabolism and reproduction also can induce distinct patterns of expression of the MIP and schistosomin genes. The stimulus-dependent expression of multiple neuropeptide genes enormously increases the adaptive potential of a peptidergic neuron. We suggest that this contributes significantly to the information-handling capacity of the brain.

MeSH Terms

Amino Acid Sequence Animals Gene Expression Intercellular Signaling Peptides and Proteins Lymnaea/cytology,genetics,metabolism Molecular Sequence Data Neurons/cytology,metabolism Neuropeptides/chemistry,genetics Neurosecretory Systems/metabolism Peptides/chemistry,physiology

Chemicals

Intercellular Signaling Peptides and Proteins Neuropeptides Peptides insulin-related neuropeptide schistosomin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Geraerts W P

Faculty of Biology, Vrije Universiteit, Amsterdam, The Netherlands.

Smit A B

Li K W

Hordijk P L

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23 references, click to expand

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Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01928165

Published

1992-05-15

Pages

464-73

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01928165

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