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PMID: 1600747 Published · ppublish English Journal Article Review

RNA virus populations as quasispecies.

Current topics in microbiology and immunology ·Vol. 176 ·1992-00-00 ·Pages 1-20

Holland JJ, De La Torre JC, Steinhauer DA

Abstract

RNA virus mutation frequencies generally approach maximum tolerable levels, and create complex indeterminate quasispecies populations in infected hosts. This usually favors extreme rates of evolution, although periods of relative stasis or equilibrium, punctuated by rapid change may also occur (as for other life forms). Because complex quasispecies populations of RNA viruses arise probabilistically and differentially in every host, their compositions and exact roles in disease pathogenesis are indeterminate and their directions of evolution, and the nature and timing of "new" virus outbreaks are unpredictable.

MeSH Terms
Biological Evolution Humans Mutation RNA Viruses/genetics,pathogenicity Species Specificity Virus Diseases/etiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Holland J J
Department of Biology, University of California, San Diego, La Jolla 92093-0116.
De La Torre J C
Steinhauer D A
Article Info
Journal
Current topics in microbiology and immunology
Abbr.
Curr Top Microbiol Immunol
ISSN
0070-217X
Published
1992-00-00
Pages
1-20
Language
English
Region
Germany
NLM ID
0110513
Subset
IM
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