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PMID: 16000410 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Highly pathogenic H5N1 influenza virus infection in migratory birds.

Science (New York, N.Y.) ·Vol. 309 ·No. 5738 ·2005-08-19 ·Pages 1206

Liu J, Xiao H, Lei F, Zhu Q, Qin K, Zhang XW, Zhang XL, Zhao D, Wang G, Feng Y, Ma J, Liu W, Wang J, Gao GF

Abstract

H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for a variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, in May and June 2005, in which more than a thousand birds were affected. Pancreatic necrosis and abnormal neurological symptoms were the major clinical features. Sequencing of the complete genomes of four H5N1 AIV strains revealed them to be reassortants related to a peregrine falcon isolate from Hong Kong and to have known highly pathogenic characteristics. Experimental animal infections reproduced typical highly pathogenic AIV infection symptoms and pathology.

MeSH Terms

Amino Acid Sequence Animal Migration Animals Birds/virology Charadriiformes/virology Chickens China/epidemiology Disease Outbreaks/veterinary Geese/virology Genome, Viral Influenza A Virus, H5N1 Subtype Influenza A virus/classification,genetics,isolation & purification,pathogenicity Influenza in Birds/epidemiology,pathology,virology Mice Molecular Sequence Data Phylogeny Reassortant Viruses/genetics,pathogenicity Virulence

Authors & Affiliations

14 authors, click to expand affiliations / ORCID

Liu J

College of Veterinary Medicine, China Agricultural University, Beijing 100094, China. jhl@cau.edu.cn

Xiao H

Lei F

Zhu Q

Qin K

Zhang X-W

Zhang X-L

Zhao D

Wang G

Feng Y

Ma J

Liu W

Wang J

Gao G F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1115273

jhl@cau.edu.cn

Published

2005-08-19

Epub

2005-00-06

Pages

1206

Language

English

Region

United States

NLM ID

0404511

Subset

Databases

GENBANK

DQ100542, DQ100543, DQ100544, DQ100545, DQ100546, DQ100547, DQ100548, DQ100549, DQ100550, DQ100551, DQ100552, DQ100553, DQ100554, DQ100555, DQ100556, DQ100557, DQ100558, DQ100559, DQ100560, DQ100561, DQ100562, DQ100563, DQ100564, DQ100565, DQ100566, DQ100567, DQ100568, DQ100569, DQ100570, DQ100571, DQ100572, DQ100573

Corrections

CommentIn

PMID: 16224004

External Links

PubMed source DOI: 10.1126/science.1115273 View journal details

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Highly pathogenic H5N1 influenza virus infection in migratory birds.

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