The role of cytosolic Ca2+ in cell injury, necrosis and apoptosis.
作者:
Trump(B F),Berezesky(I K)
状态:
发布时间1992-07-10
, 更新时间 2013-11-21
期刊:
Curr Opin Cell Biol
摘要:
Increases in cytosolic Ca2+ are believed to be a pivotal signal in the regulation of cell injury, cell death, cell proliferation, cellular differentiation and cellular aging. Changes in the concentration of cytosolic Ca2+ are involved in both acute and chronic cell injury, as well as in accidental or programmed cell death. Signalling in all of these phenomena is dependent on mediated activities of a number of intracellular factors, including phospholipases, proteases and endonucleases. The coordinate regulation of these factors, as well as of oncogene activation, seems to play a role both in the processes of cell injury and cell death, and in the recovery from injury in sublethally injured cells.