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PMID: 15965273 Published · ppublish English Journal Article Review

Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis.

Medical oncology (Northwood, London, England) ·Vol. 22 ·No. 2 ·2005-00-00 ·Pages 113-21

Burgos JS

Abstract

The aim of this study was to discuss the relevance of the Epstein-Barr virus (EBV) in the nasopharyngeal carcinoma (NPC), analyzing the variations of several molecules potentially involved in the pathogenesis of this cancer. EBV was detected in all the NPC samples by several techniques including PCR, in situ hybridization, and immunohistochemical methodologies. CD21 membrane receptor was absent after EBV infection, being a differential morphological feature of the tumoral cells. Latent membrane protein-1 (LMP1), an oncogenic viral product, was detected in a high percentage of samples, supporting a role for EBV in the pathogenesis of NPC. Bcl-2, an anti-apoptotic protein up-regulated by LMP1, was also overexpressed, coinciding with the majority of samples positive for LMP1. Finally, p53 presented abnormalities only in a low percentage of samples. These results reinforce the role of the EBV in the NPC discussing several potential mechanisms of pathogenesis in this neoplasia.

MeSH Terms
Epstein-Barr Virus Infections/metabolism,pathology,virology Herpesvirus 4, Human/pathogenicity Humans Nasopharyngeal Neoplasms/metabolism,pathology,virology Proto-Oncogene Proteins c-bcl-2/metabolism Tumor Suppressor Protein p53/metabolism Viral Proteins/analysis,genetics
Chemicals
Proto-Oncogene Proteins c-bcl-2 Tumor Suppressor Protein p53 Viral Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Burgos Javier S
Centro de Biología Molecular Severo Ochoa - C.S.I.C., Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain. jburgos@cbm.uam.es
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Article Info
Journal
Medical oncology (Northwood, London, England)
Abbr.
Med Oncol
ISSN
1357-0560
DOI
10.1385/MO:22:2:113
Email
jburgos@cbm.uam.es
Published
2005-00-00
Pages
113-21
Language
English
Region
United States
NLM ID
9435512
Subset
IM
External Links
PubMed source DOI: 10.1385/MO:22:2:113 View journal details
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