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PMID: 1596084 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.

Annals of neurology ·Vol. 31 ·No. 5 ·1992-05-00 ·Pages 488-94

Baram TZ, Hirsch E, Snead OC, Schultz L

Abstract

The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin-releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days. Rat pups carried bipolar electrodes implanted in subcortical limbic structures, as well as cortical electrodes and intracerebroventricular cannulae. The administration of corticotropin-releasing hormone produced age-specific seizures within minutes, which correlated with rhythmic amygdala discharges. Paroxysmal hippocampal and cortical discharges developed subsequently in some rats. Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala.

MeSH Terms
Aging/physiology Amygdala/physiology Animals Animals, Newborn Behavior, Animal/drug effects Corticotropin-Releasing Hormone/pharmacology Dose-Response Relationship, Drug Electroencephalography Electromyography Jaw/physiopathology Myoclonus/physiopathology Rats Rats, Inbred Strains Seizures/chemically induced,physiopathology Stereotyped Behavior
Chemicals
Corticotropin-Releasing Hormone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Baram T Z
Department of Neurology, University of Southern California, Los Angeles.
Hirsch E
Snead O C
Schultz L
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Article Info
Journal
Annals of neurology
Abbr.
Ann Neurol
ISSN
0364-5134
DOI
10.1002/ana.410310505
Published
1992-05-00
Pages
488-94
Language
English
Region
United States
NLM ID
7707449
PMCID
PMC3153947
Subset
IM
Grants
NINDS NIH HHS · K08 NS001307 · United States
NINDS NIH HHS · K08 NS001307-05 · United States
External Links
PubMed source DOI: 10.1002/ana.410310505 PMC Full Text View journal details
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