Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery.

Animals Benzamides/chemistry,therapeutic use Benzenesulfonates/chemistry,therapeutic use Clinical Trials as Topic Diphenylamine/analogs & derivatives,chemistry,therapeutic use Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors,metabolism Humans Molecular Structure Neoplasms/drug therapy,physiopathology Niacinamide/analogs & derivatives Phenylurea Compounds Protein Kinase Inhibitors/chemistry,therapeutic use Proto-Oncogene Proteins c-raf/antagonists & inhibitors,metabolism Pyridines/chemistry,therapeutic use Signal Transduction/drug effects,physiology Sorafenib

Benzamides Benzenesulfonates Phenylurea Compounds Protein Kinase Inhibitors Pyridines Niacinamide mirdametinib Diphenylamine Sorafenib Proto-Oncogene Proteins c-raf Extracellular Signal-Regulated MAP Kinases