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PMID: 15954863 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Ras plasma membrane signalling platforms.

The Biochemical journal ·Vol. 389 ·No. Pt 1 ·2005-07-01 ·Pages 1-11

Hancock JF, Parton RG

Abstract

The plasma membrane is a complex, dynamic structure that provides platforms for the assembly of many signal transduction pathways. These platforms have the capacity to impose an additional level of regulation on cell signalling networks. In this review, we will consider specifically how Ras proteins interact with the plasma membrane. The focus will be on recent studies that provide novel spatial and dynamic insights into the micro-environments that different Ras proteins utilize for signal transduction. We will correlate these recent studies suggesting Ras proteins might operate within a heterogeneous plasma membrane with earlier biochemical work on Ras signal transduction.

MeSH Terms
Cell Membrane/chemistry,metabolism Fluorescence Recovery After Photobleaching Protein Binding Signal Transduction ras Proteins/chemistry,metabolism
Chemicals
ras Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hancock John F
Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia. j.hancock@imb.uq.edu.au
Parton Robert G
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
1470-8728
DOI
10.1042/BJ20050231
Email
j.hancock@imb.uq.edu.au
Published
2005-07-01
Pages
1-11
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1184533
Subset
IM
Grants
NIGMS NIH HHS · R01 GM066717 · United States
NIGMS NIH HHS · R01 GM066717-03 · United States
NIGMS NIH HHS · GM066717 · United States
External Links
PubMed source DOI: 10.1042/BJ20050231 PMC Full Text View journal details
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