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PMID: 15950900 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

What has senescence got to do with cancer?

Cancer cell ·Vol. 7 ·No. 6 ·2005-06-00 ·Pages 505-12

Dimri GP

Abstract

Cancer therapeutics are primarily thought to work by inducing apoptosis in tumor cells. However, various tumor suppressors and oncogenes have been shown to regulate senescence in normal cells, and senescence bypass appears to be an important step in the development of cancer. Cellular senescence limits the replicative capacity of cells, thus preventing the proliferation of cells that are at different stages of malignancy. A recent body of evidence suggests that induction of senescence can be exploited as a basis for cancer therapy.

MeSH Terms
Antineoplastic Agents/pharmacology,therapeutic use Cellular Senescence/drug effects,physiology Humans Models, Biological Neoplasm Proteins/physiology Neoplasms/drug therapy,physiopathology Nuclear Proteins/physiology Promyelocytic Leukemia Protein Retinoblastoma Protein/physiology Signal Transduction/drug effects,physiology Telomere/physiology Transcription Factors/physiology Tumor Suppressor Protein p14ARF/physiology Tumor Suppressor Protein p53/physiology Tumor Suppressor Proteins/physiology
Chemicals
Antineoplastic Agents Neoplasm Proteins Nuclear Proteins Promyelocytic Leukemia Protein Retinoblastoma Protein Transcription Factors Tumor Suppressor Protein p14ARF Tumor Suppressor Protein p53 Tumor Suppressor Proteins PML protein, human
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Dimri Goberdhan P
Division of Cancer Biology, Department of Medicine, ENH Research Institute, and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 1001 University Place, Evanston, IL 60201, USA. gdimri@enh.org
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Article Info
Journal
Cancer cell
Abbr.
Cancer Cell
ISSN
1535-6108
DOI
10.1016/j.ccr.2005.05.025
Email
gdimri@enh.org
Published
2005-06-00
Pages
505-12
Language
English
Region
United States
NLM ID
101130617
PMCID
PMC1769521
Subset
IM
Grants
NCI NIH HHS · R01 CA094150 · United States
NCI NIH HHS · R01 CA 094150 · United States
External Links
PubMed source DOI: 10.1016/j.ccr.2005.05.025 PMC Full Text View journal details
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