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PMID: 15939787 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man.

The Journal of experimental medicine ·Vol. 201 ·No. 11 ·2005-06-06 ·Pages 1709-14

Bowen DG, Walker CM

Abstract

The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I-restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.

MeSH Terms
Animals Antigenic Modulation/genetics CD8-Positive T-Lymphocytes/immunology Epitopes, T-Lymphocyte/genetics,immunology Evolution, Molecular Hepacivirus/genetics,immunology Hepatitis C/immunology Hepatitis C Antigens/genetics,immunology Humans Mutation Pan troglodytes/genetics,immunology T-Lymphocyte Subsets/immunology
Chemicals
Epitopes, T-Lymphocyte Hepatitis C Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bowen David G
Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, OH 43205, USA.
Walker Christopher M
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34 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.20050808
Published
2005-06-06
Pages
1709-14
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2213256
Subset
IM
Grants
NIAID NIH HHS · U19 AI048231 · United States
NIAID NIH HHS · R01 AI47367 · United States
NIAID NIH HHS · U19 AI48231 · United States
External Links
PubMed source DOI: 10.1084/jem.20050808 PMC Full Text View journal details
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