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PMID: 15937486 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.

Nature immunology ·Vol. 6 ·No. 7 ·2005-07-00 ·Pages 698-706

Laouar A, Haridas V, Vargas D, Zhinan X, Chaplin D, van Lier RA, Manjunath N

Abstract

One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.

MeSH Terms
Animals Antigen Presentation/immunology Antigens, CD/immunology CD27 Ligand Cell Differentiation/immunology Flow Cytometry Immunohistochemistry Intestinal Mucosa/cytology,immunology,microbiology Listeria monocytogenes/immunology Listeriosis/immunology,pathology Lymphocyte Activation/immunology Membrane Proteins/immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Phagocytosis/immunology Specific Pathogen-Free Organisms T-Lymphocytes/cytology,immunology Tumor Necrosis Factor Receptor Superfamily, Member 7/immunology
Chemicals
Antigens, CD CD27 Ligand Cd70 protein, mouse Membrane Proteins Tumor Necrosis Factor Receptor Superfamily, Member 7
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Laouar Amale
The CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Haridas Viraga
Vargas Dorothy
Zhinan Xia
Chaplin David
van Lier Rene A W
Manjunath N
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2908
DOI
10.1038/ni1212
Published
2005-07-00
Epub
2005-00-05
Pages
698-706
Language
English
Region
United States
NLM ID
100941354
PMCID
PMC1444945
Subset
IM
Grants
NIAID NIH HHS · R01 AI046566 · United States
NIAID NIH HHS · R21 AI046566 · United States
NIAID NIH HHS · AI46566 · United States
Corrections
CommentIn
PMID: 15970934
External Links
PubMed source DOI: 10.1038/ni1212 PMC Full Text View journal details
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