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PMID: 159264 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Suppression of lymphocyte response to concanavalin A by mucopolysaccharide material from Treponema pallidum-infected rabbits.

Infection and immunity ·Vol. 26 ·No. 1 ·1979-10-00 ·Pages 64-9

Bey RF, Johnson RC, Fitzgerald TJ

Abstract

The testicular fluid and serum from rabbits infected intratesticularly with Treponema pallidum inhibited the mitogenic response of normal rabbit peripheral blood lymphocytes to concanavalin A. Mucopolysaccharide material present in the testicular fluid and serum was associated with the lymphocyte-inhibitory activity. Degradation of the mucopolysaccharide material with hyaluronidase resulted in the loss of the inhibitory activity of testicular fluid and serum of T. pallidu-infected rabbits.

MeSH Terms
Animals Concanavalin A Glycosaminoglycans/blood,physiology Hyaluronoglucosaminidase/pharmacology Lymphocyte Activation Male Rabbits Syphilis/blood,immunology
Chemicals
Glycosaminoglycans Concanavalin A Hyaluronoglucosaminidase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bey R F
Johnson R C
Fitzgerald T J
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23 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.26.1.64-69.1979
Published
1979-10-00
Pages
64-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414575
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.26.1.64-69.1979 PMC Full Text View journal details
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