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PMID: 15905365 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

tRNA actively shuttles between the nucleus and cytosol in yeast.

Science (New York, N.Y.) ·Vol. 309 ·No. 5731 ·2005-07-01 ·Pages 140-2

Takano A, Endo T, Yoshihisa T

Abstract

Previous evidence suggested that transfer RNAs (tRNAs) cross the nuclear envelope to the cytosol only once after maturing in the nucleus. We now present evidence for nuclear import of tRNAs in yeast. Several export mutants accumulate mature tRNAs in the nucleus even in the absence of transcription. Import requires energy but not the Ran cycle. These results indicate that tRNAs shuttle between the nucleus and cytosol.

MeSH Terms
Active Transport, Cell Nucleus Adenosine Triphosphate/metabolism Cell Nucleus/genetics,metabolism Cytosol/metabolism Introns Mutation RNA Precursors/metabolism RNA, Fungal/metabolism RNA, Transfer/genetics,metabolism RNA, Transfer, Amino Acid-Specific/metabolism RNA, Transfer, Amino Acyl/metabolism RNA, Transfer, Ile/metabolism RNA, Transfer, Pro/metabolism RNA, Transfer, Tyr/metabolism Saccharomyces cerevisiae/genetics,growth & development,metabolism Transcription, Genetic ran GTP-Binding Protein/metabolism
Chemicals
RNA Precursors RNA, Fungal RNA, Transfer, Amino Acid-Specific RNA, Transfer, Amino Acyl RNA, Transfer, Ile RNA, Transfer, Pro RNA, Transfer, Tyr Adenosine Triphosphate RNA, Transfer ran GTP-Binding Protein
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Takano Akira
Department of Chemistry, Graduate School of Science, Japan Science and Technology Corporation, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
Endo Toshiya
Yoshihisa Tohru
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1113346
Published
2005-07-01
Epub
2005-00-19
Pages
140-2
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.1113346 View journal details
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