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题目:: Synaptic connections of cone bipolar cells that express the neurokinin 1 receptor in the rabbit retina.
作者:: Kim(In-Beom),Park(Mi Ra),Kang(Tae-Hoon),Kim(Hyun-Ju),Lee(Eun-Jin),Ahn(Myung-Douk),Chun(Myung-Hoon)
状态:: 发布时间2005-07-06 , 更新时间 2008-11-21
期刊:: Cell Tissue Res
摘要:: We have investigated and further characterized, in the rabbit retina, the synaptic connectivity of the ON-type cone bipolar cells that are immunoreactive for an antibody against the neurokinin-1 receptor (NK1R). NK1R-immunoreactive bipolar cell axons terminate in stratum 4 of the inner plexiform layer. The axons of NK1R-positive bipolar cells receive synaptic inputs from amacrine cells through conventional synapses and from putative AII amacrine cells via gap junctions. The major outputs from NK1R-positive bipolar cells make contacts with amacrine cell processes. The most frequent postsynaptic dyads comprise two amacrine cell processes. Double-labeling experiments with antibodies against NK1R and either calretinin or glycine have demonstrated that NK1R-immunoreactive bipolar cells form gap junctions with AII amacrine cells. Thus, NK1R-positive cone bipolar cells, together with calbindin-positive cone bipolar cells, may play an important role in transferring rod signals to the ON-type ganglion cells of the cone pathway in the rabbit retina.
语言:: eng
DOI:: 10.1007/s00441-005-1122-8

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