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PMID: 15901721 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Evolution of subspecies of Francisella tularensis.

Journal of bacteriology ·Vol. 187 ·No. 11 ·2005-06-00 ·Pages 3903-8

Svensson K, Larsson P, Johansson D, Byström M, Forsman M, Johansson A

Abstract

Analysis of unidirectional genomic deletion events and single nucleotide variations suggested that the four subspecies of Francisella tularensis have evolved by vertical descent. The analysis indicated an evolutionary scenario where the highly virulent F. tularensis subsp. tularensis (type A) appeared before the less virulent F. tularensis subsp. holarctica (type B). Compared to their virulent progenitors, attenuated strains of F. tularensis exhibited specific unidirectional gene losses.

MeSH Terms

Evolution, Molecular Francisella tularensis/classification,genetics,pathogenicity Gene Deletion Genome, Bacterial Molecular Sequence Data Oligonucleotide Array Sequence Analysis Phylogeny Virulence

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Svensson Kerstin

Department of NBC-Analysis, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden.

Larsson Pär

Johansson Daniel

Byström Mona

Forsman Mats

Johansson Anders

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/JB.187.11.3903-3908.2005

Published

2005-06-00

Pages

3903-8

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC1112057

Subset

Databases

GENBANK

AF469614, AF469615, AF469616, AF469617, AF469618, AF469619, AY794406, AY794434, AY794435, AY794543

External Links

PubMed source DOI: 10.1128/JB.187.11.3903-3908.2005 PMC Full Text View journal details

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Evolution of subspecies of Francisella tularensis.

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