Biotin synthase: enzyme or reactant?

Chemistry & biology ·Vol. 12 ·No. 4 ·2005-04-00 ·Pages 409-10

Jarrett JT

Abstract

Biotin synthase catalyzes formation of a thiophane ring through a radical mechanism that is difficult to reconstitute in vitro. Choi-Rhee and Cronan measure a turnover of 20-60 equivalents of biotin in vivo, but also find that turnover renders the protein susceptible to proteolytic destruction.

MeSH Terms

Biotin/biosynthesis,chemistry Escherichia coli/enzymology,metabolism Models, Molecular Protein Conformation Sulfurtransferases/chemistry,metabolism

Chemicals

Biotin Sulfurtransferases biotin synthetase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Jarrett Joseph T

Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.

Article Info

Journal

Chemistry & biology

Abbr.

Chem Biol

ISSN

1074-5521

DOI

10.1016/j.chembiol.2005.04.003

Published

2005-04-00

Pages

409-10

Language

English

Region

United States

NLM ID

9500160

Subset

Grants

NIGMS NIH HHS · R01 GM059175-06 · United States

Corrections

CommentOn

PMID: 15850983

External Links

PubMed source DOI: 10.1016/j.chembiol.2005.04.003 View journal details

Analysis Services

Biotin synthase: enzyme or reactant?

Contact

WeChat Official Account