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PMID: 15849806 Published · ppublish English Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Systematic Review

Phase I/II enzyme gene polymorphisms and esophageal cancer risk: a meta-analysis of the literature.

World journal of gastroenterology ·Vol. 11 ·No. 17 ·2005-05-07 ·Pages 2531-8

Yang CX, Matsuo K, Wang ZM, Tajima K

Abstract

Phase I/II enzymes metabolize environmental carcin-ogens and several functional polymorphisms have been reported in their encoding genes. Although their significance with regard to esophageal carcinogenicity has been examined epidemiologically, it remains controversial. The present systematic review of the literature was performed to clarify associations. Eligible studies were case-control or cohort studies published until September 2004 that were written in any language. From PubMed and a manual review of reference lists in relevant review articles, we obtained 16 studies related to the CYP1A1 Ile-Val substitution in exon 7, CYP1A1 MspI polymorphisms, CYP2E1 RsaI polymorphisms, GSTM1 null type, GSTT1 null type and GSTP1 Ile104Val. All were of case-control design. Summary statistics were odds ratios (ORs) comparing heterozygous-, homozygous-non-wild type or these two in combination with the homozygous wild type, or the null type with the non-null type for GSTM1 and GSTT1. A random effect model was used to estimate the summary ORs. A meta-regression analysis was applied to explore sources of heterogeneity. Individuals with the Ile-Val substitution in CYP1A1 exon 7 had increased esophageal cancer risk, with ORs (95%CI) compared with Ile/Ile of 1.37 (1.09-1.71), 2.52 (1.62-3.91) and 1.44 (1.17-1.78) for Ile-Val, Val/Val genotype and the combined group. No significant association was found between esophageal cancer risk and the other genetic parameters. A significant association exists between the CYP1A1 Ile-Val polymorphism and risk of esophageal cancer. Polymorphisms that increase the internal exposure to activated carcinogens may increase the risk of esophageal cancer.

MeSH Terms
Cytochrome P-450 CYP1A1/genetics Cytochrome P-450 CYP2E1/genetics Esophageal Neoplasms/epidemiology,genetics Glutathione S-Transferase pi Glutathione Transferase/genetics Humans Isoenzymes/genetics Polymorphism, Genetic Risk Factors
Chemicals
Isoenzymes Cytochrome P-450 CYP2E1 Cytochrome P-450 CYP1A1 GSTP1 protein, human Glutathione S-Transferase pi Glutathione Transferase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yang Chun-Xia
Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, Sichuan Province, China.
Matsuo Keitaro
Wang Zhi-Ming
Tajima Kazuo
References (56)
56 references, click to expand
  1. Cytochrome P450 expression in oesophageal cancer.
    Gut. 1994 May;35(5):599-603 PMID: 8200549
  2. The glutathione S-transferases: influence of polymorphism on cancer susceptibility.
    IARC Sci Publ. 1999;(148):231-49 PMID: 10493261
  3. Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
    Oncol Rep. 2003 Sep-Oct;10(5):1615-23 PMID: 12883749
  4. [Genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase P1 and susceptibility to esophageal cancer].
    Zhonghua Zhong Liu Za Zhi. 1998 Mar;20(2):94-7 PMID: 10920953
  5. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.
    Biochem J. 1994 May 15;300 ( Pt 1):271-6 PMID: 8198545
  6. Decreased hepatic drug metabolising enzyme activity in rats with nitrosamine-induced tumours.
    Drug Metabol Drug Interact. 2002;19(1):13-27 PMID: 12222751
  7. Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation.
    Drug Metab Rev. 1990;22(2-3):147-59 PMID: 2272285
  8. Depentylation of [3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms.
    Cancer Res. 1999 Jan 1;59(1):91-8 PMID: 9892192
  9. Absence of a differential induction of cytochrome P450 2E1 by different alcoholic beverages in rats: implications for the aetiology of human oesophageal cancer.
    Arch Toxicol. 1997;71(11):690-5 PMID: 9363842
  10. Mechanisms of esophageal cancer development in Brazilians.
    Mutat Res. 2003 Nov;544(2-3):365-73 PMID: 14644339
  11. Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1.
    Cancer Epidemiol Biomarkers Prev. 1998 Nov;7(11):1013-8 PMID: 9829710
  12. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
    J Clin Gastroenterol. 1997 Dec;25(4):568-75 PMID: 9451664
  13. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone.
    Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):495-500 PMID: 10385138
  14. Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison.
    Cancer Lett. 2004 Sep 30;213(2):195-202 PMID: 15327835
  15. [Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma].
    Zhonghua Liu Xing Bing Xue Za Zhi. 2000 Dec;21(6):420-3 PMID: 11860825
  16. Experimental evidence for cancer preventive elements in foods.
    Cancer Lett. 1997 Mar 19;114(1-2):11-7 PMID: 9103245
  17. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma.
    Carcinogenesis. 2002 Nov;23 (11):1851-9 PMID: 12419833
  18. [Progress in researches on the relationship between genetic polymorphisms of alcohol-metabolizing enzymes and cancers].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001 Feb;18(1):62-5 PMID: 11172647
  19. Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
    Alcohol Clin Exp Res. 2002 Aug;26(8 Suppl):15S-19S PMID: 12198369
  20. Characterization of cytochrome P450 expression in human oesophageal mucosa.
    Carcinogenesis. 1999 Feb;20(2):243-8 PMID: 10069460
  21. Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene.
    Alcohol Clin Exp Res. 2003 Aug;27(8 Suppl):42S-46S PMID: 12960506
  22. Expression of cytochrome P450s and glutathione S-transferases in human esophagus with squamous-cell carcinomas.
    Carcinogenesis. 1996 Jul;17(7):1477-81 PMID: 8706252
  23. Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer risk.
    Cancer Res. 1992 Dec 1;52(23):6712-5 PMID: 1423319
  24. Genetic polymorphism of aldehyde dehydrogenase 2 in patients with upper aerodigestive tract cancer.
    Alcohol Clin Exp Res. 1999 Apr;23 (4 Suppl):17S-20S PMID: 10235272
  25. Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma.
    Cancer Detect Prev. 2003;27(2):139-46 PMID: 12670526
  26. Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians.
    Alcohol Clin Exp Res. 1996 Sep;20(6):1033-7 PMID: 8892524
  27. Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States).
    Cancer Causes Control. 2003 May;14(4):339-46 PMID: 12846365
  28. Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.
    Carcinogenesis. 1997 Jul;18(7):1285-9 PMID: 9230269
  29. Epigenetic patterns in the progression of esophageal adenocarcinoma.
    Cancer Res. 2001 Apr 15;61(8):3410-8 PMID: 11309301
  30. Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans.
    Pharmacogenetics. 1994 Oct;4(5):242-6 PMID: 7894496
  31. Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China.
    Cancer Lett. 2002 Dec 15;188(1-2):95-102 PMID: 12406553
  32. CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.
    Carcinogenesis. 2002 Apr;23 (4):611-6 PMID: 11960914
  33. Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an.
    World J Gastroenterol. 2002 Feb;8(1):49-53 PMID: 11833070
  34. Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: case-control studies of Japanese Brazilians and non-Japanese Brazilians.
    Cancer Epidemiol Biomarkers Prev. 2000 Jul;9(7):675-80 PMID: 10919737
  35. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.
    Carcinogenesis. 1997 Apr;18(4):641-4 PMID: 9111193
  36. [Detection of malondialdehyde-DNA adduct level by 32P-postlabeling assay in normal human esophageal epithelium and esophageal squamous cell carcinoma].
    Zhonghua Zhong Liu Za Zhi. 2001 Nov;23(6):473-6 PMID: 11859713
  37. Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases.
    Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1480-4 PMID: 8108434
  38. Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
    Cancer Epidemiol Biomarkers Prev. 2000 Jun;9(6):551-6 PMID: 10868687
  39. Role of ethanol-inducible cytochrome P450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols.
    Biochem Pharmacol. 1991 Jun 15;41(12):1895-902 PMID: 2039543
  40. Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan.
    Br J Cancer. 2002 Aug 27;87(5):529-32 PMID: 12189551
  41. Allele frequencies for glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence.
    Clin Chem Lab Med. 2003 Apr;41(4):600-5 PMID: 12747608
  42. Association between GSTM1*0 and squamous dysplasia of the esophagus in the high risk region of Linxian, China.
    Cancer Lett. 2000 Aug 1;156(1):73-81 PMID: 10840162
  43. CYP1A1 polymorphisms and lung cancer risk: a meta-analysis.
    Pharmacogenetics. 2000 Mar;10(2):105-14 PMID: 10761998
  44. CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus.
    Int J Cancer. 1997 Apr 10;71(2):192-5 PMID: 9139841
  45. Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking.
    Cancer. 1997 Sep 1;80(5):852-7 PMID: 9307183
  46. Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer.
    Cancer Epidemiol Biomarkers Prev. 2003 Dec;12(12):1509-17 PMID: 14693745
  47. Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver.
    Mutagenesis. 2002 May;17(3):251-6 PMID: 11971997
  48. Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma.
    Cancer Res. 1999 Feb 1;59(3):586-9 PMID: 9973204
  49. B- and T-lymphocyte micronuclei in chimney sweeps with respect to genetic polymorphism for CYP1A1 and GST1 (class Mu).
    Mutat Res. 1993 Oct;289(2):187-95 PMID: 7690887
  50. Metabolism of N-nitrosobenzylmethylamine by human cytochrome P-450 enzymes.
    J Toxicol Environ Health A. 1999 Dec 10;58(7):397-411 PMID: 10616189
  51. [Glutathione S-transferase M1, T1 genotypes and the risk of esophageal cancer: a case-control study].
    Zhonghua Liu Xing Bing Xue Za Zhi. 1998 Aug;19(4):195-9 PMID: 10322669
  52. Association between genetic polymorphisms of glutathione S-transferase P1 and N-acetyltransferase 2 and susceptibility to squamous-cell carcinoma of the esophagus.
    Int J Cancer. 1998 Oct 23;79(5):517-20 PMID: 9761122
  53. Genetic polymorphisms of p53 and GSTP1,but not NAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus.
    Int J Cancer. 2000 Sep 20;89(5):458-64 PMID: 11008209
  54. Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis.
    Am J Gastroenterol. 2000 Oct;95(10):2958-64 PMID: 11051375
  55. Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese.
    Cancer Epidemiol Biomarkers Prev. 2002 Jan;11(1):29-34 PMID: 11815398
  56. Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers.
    Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):3-28 PMID: 10667460
Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
1007-9327
DOI
10.3748/wjg.v11.i17.2531
Published
2005-05-07
Pages
2531-8
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4305738
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.v11.i17.2531 PMC Full Text View journal details
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