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题目:: A major role for memory CD4 T cells in the control of lymphopenia-induced proliferation of naive CD4 T cells.
作者:: Bourgeois(Christine),Kassiotis(George),Stockinger(Brigitta)
状态:: 发布时间2005-04-21 , 更新时间 2016-12-03
期刊:: J Immunol
摘要:: In a state of lymphopenia, naive and memory CD4 T cells compete with each other for expansion at the expense of naive T cells. This competition prevents the proliferation as well as the phenotypic and functional conversion of naive T cells to "memory-like" T cells and may consequently prevent immune pathology frequently associated with lymphopenia-induced proliferation of naive cells. However, in T cell replete mice, memory T cells do not compete with naive T cells, indicating independent homeostatic control of naive and memory CD4 T cells in conditions that do not involve profound lymphopenia. Moreover, within the memory compartment, subsequent generation of new memory T cells precludes the survival of memory-like T cells. Thus, memory T cells have a major role in the control of lymphopenia-induced proliferation of naive cells because they inhibit both the generation of memory-like T cells and their persistence within the memory compartment.
语言:: eng
DOI:

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