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题目:: Mast cells enhance T cell activation: Importance of mast cell-derived TNF.
作者:: Nakae(Susumu),Suto(Hajime),Kakurai(Maki),Sedgwick(Jonathon D),Tsai(Mindy),Galli(Stephen J)
状态:: 发布时间2005-05-04 , 更新时间 2016-10-19
期刊:: Proc Natl Acad Sci U S A
摘要:: Mast cells are not only important effector cells in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute to T cell-mediated disorders. However, the mechanisms by which mast cells might influence T cells in such settings are not fully understood. We find that mast cells can enhance proliferation and cytokine production in multiple T cell subsets. Mast cell-dependent enhancement of T cell activation can be promoted by FcepsilonRI-dependent mast cell activation, TNF production by both mast cells and T cells, and mast cell-T cell contact. However, at high concentrations of cells, mast cells can promote T cell activation independent of IgE or TNF. Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production.
语言:: eng
DOI:

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