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题目:: Unveiling the mechanisms of cell-cell fusion.
作者:: Chen(Elizabeth H),Olson(Eric N)
状态:: 发布时间2005-04-15 , 更新时间 2008-11-21
期刊:: Science
摘要:: Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by contrasting it with virus-cell and intracellular vesicle fusion. We also consider how proteins involved in general aspects of membrane dynamics have been co-opted to control fusion of diverse cell types by coupling with specialized proteins involved in cell-cell recognition, adhesion, and signaling.
语言:: eng
DOI:: 10.1126/science.1104799

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