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题目:
Unveiling the mechanisms of cell-cell fusion.
作者:
Chen(Elizabeth H),Olson(Eric N)
状态:
发布时间2005-04-15 , 更新时间 2008-11-21
期刊:
Science
摘要:
Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by contrasting it with virus-cell and intracellular vesicle fusion. We also consider how proteins involved in general aspects of membrane dynamics have been co-opted to control fusion of diverse cell types by coupling with specialized proteins involved in cell-cell recognition, adhesion, and signaling.
语言:
eng
DOI:
10.1126/science.1104799

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