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PMID: 15828190 Published · ppublish English Journal Article

Characteristics and expression of tetracycline resistance in gram-negative bacteria carrying the Pseudomonas R factor RP1.

Antimicrobial agents and chemotherapy ·Vol. 6 ·No. 2 ·1974-08-00 ·Pages 183-90

Shipley PL, Olsen RH

Abstract

The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycline accumulation by RP1-containing organisms. The tetracycline resistance mechanism is inactivated at low temperatures. The effect of metabolic inhibitors on tetracycline accumulation by susceptible organisms under various conditions indicates a possible nonspecific effect of cellular energy metabolism on tetracycline uptake.

MeSH Terms
Energy Metabolism Gram-Negative Bacteria/drug effects,genetics Pseudomonas/genetics R Factors Temperature Tetracycline/pharmacokinetics Tetracycline Resistance
Chemicals
Tetracycline
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shipley P L
Olsen R H
References (21)
21 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.6.2.183
Published
1974-08-00
Pages
183-90
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444625
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.6.2.183 PMC Full Text View journal details
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