| GeneLibs

题目:: Homeostatic proliferation of B cells.
作者:: Woodland(Robert T),Schmidt(Madelyn R)
状态:: 发布时间2005-04-13 , 更新时间 2007-11-14
期刊:: Semin Immunol
摘要:: Naïve B cells introduced into a lymphopenic host undergo antigen-independent proliferation which is inhibited in a cell dose dependent manner by feedback from mature B cells. Homeostatic proliferation is a generalized lymphocyte property with B cells sharing many of the inductive and regulatory characteristics established for naïve and memory CD4+ and CD8+ T cells and NK cells. In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory.
语言:: eng
DOI:: 10.1016/j.smim.2005.02.006

文献库文献相关信息