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题目:: Multi-lineage potential of fetal cells in maternal tissue: a legacy in reverse.
作者:: Khosrotehrani(Kiarash),Bianchi(Diana W)
状态:: 发布时间2005-04-06 , 更新时间 2005-04-06
期刊:: J Cell Sci
摘要:: Fetal cells circulate in pregnant women and persist in blood and tissue for decades post-partum. The mother thus becomes chimeric. Factors that may influence such fetal cell microchimerism include histocompatibility, fetal or placental abnormalities, or a reproductive history that includes miscarriage or elective termination. Fetal cell microchimerism is associated with some maternal autoimmune diseases, such as systemic sclerosis. Moreover, a novel population of fetal cells, the pregnancy-associated progenitor cells (PAPCs), appears to differentiate in diseased or injured maternal tissue. The cellular origin of these cells is at present unknown but could be a hematopoietic stem cell, a mesenchymal stem cell, or a novel cell type. Pregnancy therefore results in the acquisition of cells with stem-cell-like properties that may influence maternal health post-partum. Rather than triggering disease, these cells may instead combat it.
语言:: eng
DOI:: 10.1242/jcs.02332

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