| GeneLibs

题目:: Frequent overexpression of cyclin D2/cyclin-dependent kinase 4 in Wilms' tumor.
作者:: Faussillon(Marine),Monnier(Lucie),Junien(Claudine),Jeanpierre(Cécile)
状态:: 发布时间2005-03-30 , 更新时间 2012-06-25
期刊:: Cancer Lett
摘要:: The expression status of the three cyclin D genes (CCND1, CCND2 and CCND3), the two cyclin D-dependent kinase genes (CDK4 and CDK6) and the p16(INK4a) gene was studied in a series of 47 Wilms' tumors, 16 normal mature kidneys and two fetal kidneys. We showed predominant overexpression of CCND2 and CDK4 compared to CCND1/D3 and CDK6 respectively. We found a specific correlation between relapse and CDK4 overexpression, but not CDK6 overexpression. We did not identify any methylation of the p16(INK4a) promoter. This suggests that dysregulation of CCND2 and CDK4 plays a specific role in WT tumorigenesis.
语言:: eng
DOI:: 10.1016/j.canlet.2004.08.010

文献库文献相关信息