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PMID: 15747113 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 371 ·No. 4 ·2005-04-00 ·Pages 295-306

van Abel M, Hoenderop JG, Bindels RJ

Abstract

The epithelial Ca(2+) channels TRPV5 and TRPV6 represent a new family of Ca(2+) channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca(2+) (re)absorption makes it a prime target for regulation to maintain Ca(2+) balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca(2+) channels.

MeSH Terms
Animals Calcium/metabolism Calcium Channels/metabolism Cell Membrane/metabolism Disease/etiology Epithelium/metabolism Humans Mice Protein Transport TRPV Cation Channels/metabolism
Chemicals
Calcium Channels TRPV Cation Channels TRPV5 protein, human TRPV6 channel Trpv5 protein, mouse Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
van Abel Monique
Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Hoenderop Joost G J
Bindels René J M
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/s00210-005-1021-2
Published
2005-04-00
Pages
295-306
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/s00210-005-1021-2 View journal details
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