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PMID: 1574000 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

An amino-proximal domain required for the localization of FtsQ in the cytoplasmic membrane, and for its biological function in Escherichia coli.

Molecular microbiology ·Vol. 6 ·No. 6 ·1992-03-00 ·Pages 715-22

Dopazo A, Palacios P, Sánchez M, Pla J, Vicente M

Abstract

The location of FtsQ, an Escherichia coli protein essential for cell division, is, under physiological conditions, in the cytoplasmic membrane facing towards the periplasmic space. An amino-proximal hydrophobic domain is required for FtsQ to reach its location and for its activity in the cell. Overexpression of modified forms of FtsQ is deleterious for the cell.

MeSH Terms

Bacterial Proteins/genetics,metabolism Base Sequence Biological Transport Cell Division Cell Membrane/metabolism Cloning, Molecular Deoxyribonucleotides Electrophoresis, Polyacrylamide Gel Escherichia coli/growth & development,metabolism Escherichia coli Proteins Genetic Complementation Test Membrane Proteins/genetics,metabolism Molecular Sequence Data Mutation Plasmids Trypsin

Chemicals

Bacterial Proteins Deoxyribonucleotides Escherichia coli Proteins FtsQ protein, E coli Membrane Proteins Trypsin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Dopazo A

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

Palacios P

Sánchez M

Pla J

Vicente M

Article Info

Journal

Molecular microbiology

Abbr.

Mol Microbiol

ISSN

0950-382X

DOI

10.1111/j.1365-2958.1992.tb01520.x

Published

1992-03-00

Pages

715-22

Language

English

Region

England

NLM ID

8712028

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2958.1992.tb01520.x View journal details

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An amino-proximal domain required for the localization of FtsQ in the cytoplasmic membrane, and for its biological function in Escherichia coli.

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