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PMID: 15727538 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Olfactory-mediated fear conditioning in mice: simultaneous measurements of fear-potentiated startle and freezing.

Behavioral neuroscience ·Vol. 119 ·No. 1 ·2005-02-00 ·Pages 329-35

Jones SV, Heldt SA, Davis M, Ressler KJ

Abstract

This study demonstrates that mice display olfactory-cued fear as measured with both freezing and fear-potentiated startle. Following a preconditioning test to measure any unconditioned responses to odor, mice received 5 pairings of a 10-s odor with a 0.25-s, 0.4-mA footshock. The next day, startle and freezing were measured in the presence and absence of the odor. Both fear measures increased after training with amyl acetate (Experiment 1) and acetophenone (Experiment 2). The enhancement of startle did not occur when the same number of odors and shocks were presented in an unpaired fashion (Experiment 3). Furthermore, mice were able to discriminate between an odor paired with shock and a nonreinforced odor (Experiment 4).

MeSH Terms
Acetophenones/pharmacology Animals Avoidance Learning Cold Temperature Conditioning, Classical Fear Male Mice Mice, Inbred C57BL Odorants Pentanols/pharmacology Reflex, Startle Smell
Chemicals
Acetophenones Pentanols amyl acetate acetophenone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Jones Seth V
Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Heldt Scott A
Davis Michael
Ressler Kerry J
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Article Info
Journal
Behavioral neuroscience
Abbr.
Behav Neurosci
ISSN
0735-7044
DOI
10.1037/0735-7044.119.1.329
Published
2005-02-00
Pages
329-35
Language
English
Region
United States
NLM ID
8302411
PMCID
PMC2881597
Subset
IM
Grants
NIMH NIH HHS · MH69884 · United States
NIMH NIH HHS · F32 MH073389-03 · United States
NIMH NIH HHS · F32 MH073389-02 · United States
NIMH NIH HHS · K01 MH069884 · United States
NIMH NIH HHS · F32 MH073389-01 · United States
External Links
PubMed source DOI: 10.1037/0735-7044.119.1.329 PMC Full Text View journal details
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