| GeneLibs

题目:: Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer.
作者:: Chang(Bao-Li),Gillanders(Elizabeth M),Isaacs(Sarah D),Wiley(Kathy E),Adams(Tamara),Turner(Aubrey R),Zheng(S Lilly),Meyers(Deborah A),Carpten(John D),Walsh(Patrick C),Trent(Jeffrey M),Xu(Jianfeng),Isaacs(William B)
状态:: 发布时间2005-02-22 , 更新时间 2010-11-18
期刊:: Cancer Lett
摘要:: To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.
语言:: eng
DOI:: 10.1016/j.canlet.2004.10.005

文献库文献相关信息