COX-2 inhibitors--lessons in drug safety.

Cardiovascular Diseases/chemically induced Celecoxib Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors/adverse effects,therapeutic use Drug Approval/legislation & jurisprudence Gastrointestinal Hemorrhage/chemically induced,prevention & control Humans Isoxazoles/adverse effects Lactones/adverse effects Membrane Proteins Prostaglandin-Endoperoxide Synthases Publishing/standards Pyrazoles/adverse effects Randomized Controlled Trials as Topic/standards Research Design Sulfonamides/adverse effects Sulfones/adverse effects United States United States Food and Drug Administration/organization & administration

Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Isoxazoles Lactones Membrane Proteins Pyrazoles Sulfonamides Sulfones rofecoxib valdecoxib parecoxib Cyclooxygenase 2 PTGS2 protein, human Prostaglandin-Endoperoxide Synthases Celecoxib