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PMID: 15710899 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis.

Dai X, Hayashi K, Nozaki H, Cheng Y, Zhao Y

Abstract

The synthetic molecule sirtinol was shown previously to activate the auxin signal transduction pathway. Here we present a combination of genetic and chemical approaches to elucidate the action mechanisms of sirtinol in Arabidopsis. Analysis of sirtinol derivatives indicated that the "active moiety" of sirtinol is 2-hydroxy-1-naphthaldehyde (HNA), suggesting that sirtinol undergoes a series of transformations in Arabidopsis to generate HNA, which then is converted to 2-hydroxy-1-naphthoic acid (HNC), which activates auxin signaling. A key step in the activation of sirtinol is the conversion of HNA to HNC, which is likely catalyzed by an aldehyde oxidase. Mutations in any of the genes that are responsible for synthesizing the molybdopterin cofactor, an essential cofactor for aldehyde oxidases, led to resistance to sirtinol, probably caused by the compromised capacity of the mutants to convert HNA to HNC. We also showed that sirtinol and HNA could bypass the auxin polar transport system and that they were transported efficiently to aerial parts of seedlings, whereas HNC and 1-naphthoic acid were essentially not absorbed by Arabidopsis seedlings, suggesting that sirtinol and HNA are useful tools for auxin studies.

MeSH Terms
Aldehyde Oxidase/physiology Arabidopsis/drug effects,genetics,metabolism Benzamides/metabolism,pharmacology Cloning, Molecular Coenzymes/biosynthesis Metalloproteins/biosynthesis Molybdenum Cofactors Naphthols/metabolism,pharmacology Pteridines Seedlings/drug effects
Chemicals
Benzamides Coenzymes Metalloproteins Molybdenum Cofactors Naphthols Pteridines sirtinol molybdenum cofactor Aldehyde Oxidase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dai Xinhua
Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0116, USA.
Hayashi Ken-ichiro
Nozaki Hiroshi
Cheng Youfa
Zhao Yunde
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2005-02-22
Epub
2005-00-14
Pages
3129-34
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC549487
Subset
IM
Grants
NIGMS NIH HHS · R01 GM068631 · United States
NIGMS NIH HHS · 1R01GM68631 · United States
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