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PMID: 15701715 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Review

Leukocyte migration and graft-versus-host disease.

Blood ·Vol. 105 ·No. 11 ·2005-06-01 ·Pages 4191-9

Wysocki CA, Panoskaltsis-Mortari A, Blazar BR, Serody JS

Abstract

Graft-versus-host disease (GVHD) remains a significant complication of allogeneic bone marrow transplantation (allo-BMT). Acute GVHD is mediated by immunocompetent donor T cells, which migrate to lymphoid tissues soon after infusion, recognize host alloantigens, and become activated upon interaction with host antigen-presenting cells (APCs). Recent work from our group and others suggests that activated effector T cells exit lymphoid tissues and traffic to mucosal sites and parenchymal target organs such as the gastrointestinal (GI) tract, liver, lung, and skin where they cause tissue damage. The molecular interactions necessary for effector cell migration during GVHD have become the focus of a growing body of research, as these interactions represent potential therapeutic targets. In this review we discuss chemokine and chemokine receptor interactions and adhesion molecules that have been shown to play roles in effector cell migration in experimental GVHD models, and we discuss a potential model for the role of chemokines during the activation phase of GVHD.

MeSH Terms
Cell Adhesion Molecules Chemokines Chemotaxis, Leukocyte/physiology Graft vs Host Disease/etiology,immunology Humans Receptors, Chemokine
Chemicals
Cell Adhesion Molecules Chemokines Receptors, Chemokine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wysocki Christian A
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
Panoskaltsis-Mortari Angela
Blazar Bruce R
Serody Jonathan S
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Article Info
Journal
Blood
Abbr.
Blood
ISSN
0006-4971
DOI
10.1182/blood-2004-12-4726
Published
2005-06-01
Epub
2005-00-08
Pages
4191-9
Language
English
Region
United States
NLM ID
7603509
PMCID
PMC1895033
Subset
IM
Grants
NIAID NIH HHS · AI 34495 · United States
NHLBI NIH HHS · HL 66308 · United States
NCI NIH HHS · CA 58233 · United States
NCI NIH HHS · CA 102052 · United States
NHLBI NIH HHS · HL 55209 · United States
NHLBI NIH HHS · HL 63452 · United States
NHLBI NIH HHS · HL 56067 · United States
External Links
PubMed source DOI: 10.1182/blood-2004-12-4726 PMC Full Text View journal details
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